Supplementary Materials

Supplementary Materials for:

Rapamycin Reverses Elevated mTORC1 Signaling in Lamin A/C–Deficient Mice, Rescues Cardiac and Skeletal Muscle Function, and Extends Survival

Fresnida J. Ramos, Steven C. Chen, Michael G. Garelick, Dao-Fu Dai, Chen-Yu Liao, Katherine H. Schreiber, Vivian L. MacKay, Elroy H. An, Randy Strong, Warren C. Ladiges, Peter S. Rabinovitch, Matt Kaeberlein,* Brian K. Kennedy*

*To whom correspondence should be addressed. E-mail: bkennedy{at}buckinstitute.org (B.K.K.); kaeber{at}uw.edu (M.K.)

Published 25 July 2012, Sci. Transl. Med. 4, 144ra103 (2012)
DOI: 10.1126/scitranslmed.3003802

This PDF file includes:

  • Fig. S1. Further characteristics of Lmna+/+ and Lmna−/− mice.
  • Fig. S2. Effect of rapamycin on survival of Lmna−/− male and female mice.
  • Fig. S3. Effect of rapamycin at different dosing regimens on survival of Lmna−/− mice.
  • Fig. S4. Effect of rapamycin on myofiber cross-sectional area in Lmna−/− mice.
  • Fig. S5. Autophagosome formation in Lmna−/− mice.

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