Supplementary Materials

Supplementary Material for:

Establishment of Antitumor Memory in Humans Using in Vitro–Educated CD8+ T Cells

Marcus O. Butler,* Philip Friedlander, Matthew I. Milstein, Mary M. Mooney, Genita Metzler, Andrew P. Murray, Makito Tanaka, Alla Berezovskaya, Osamu Imataki, Linda Drury, Lisa Brennan, Marisa Flavin, Donna Neuberg, Kristen Stevenson, Donald Lawrence, F. Stephen Hodi, Elsa F. Velazquez, Michael T. Jaklitsch, Sara E. Russell, Martin Mihm, Lee M. Nadler, Naoto Hirano

*To whom correspondence should be addressed. E-mail: marcus_butler{at}

Published 27 April 2011, Sci. Transl. Med. 80ra34 (2011)
DOI: 10.1126/scitranslmed.3002207

This PDF file includes:

  • Fig. S1. Clinical protocol time line.
  • Fig. S2. Verification of HLA-A2/MART1 peptide multimer staining.
  • Fig. S3. Adoptive transfer increased delayed-type hypersensitivity reaction to injected MART1 peptide.
  • Fig. S4. Clinical response to adoptive transfer of MART1-specific T cells in subject 5.
  • Fig. S5. Trafficking of transferred CTLs to pulmonary lesions, subject 3.
  • Fig. S6. Expansion of adoptively transferred MART1 CTLs in subject 8 treated with anti–CTLA-4 (ipilimumab) therapy.

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