Supplementary Material

Supplementary Material for:

Metabolic Signatures of Exercise in Human Plasma

Gregory D. Lewis,* Laurie Farrell, Malissa J. Wood, Maryann Martinovic, Zoltan Arany, Glenn C. Rowe, Amanda Souza, Susan Cheng, Elizabeth L. McCabe, Elaine Yang, Xu Shi, Rahul Deo, Frederick P. Roth, Aarti Asnani, Eugene P. Rhee, David M. Systrom, Marc J. Semigran, Ramachandran S. Vasan, Steven A. Carr, Thomas J. Wang, Marc S. Sabatine, Clary B. Clish, Robert E. Gerszten*

*To whom correspondence should be addressed. E-mail: rgerszten{at}partners.org (R.E.G.); glewis{at}partners.org (G.D.L.)

Published 26 May 2010, Sci. Transl. Med.2, 33ra37 (2010)
DOI: 10.1126/scitranslmed.3001006

This PDF file includes:

  • Materials and Methods
  • Fig. S1. Relation between plasma lactate concentrations measured by LC-MS and the MGH clinical chemistry laboratory.
  • Fig. S2. Dendrogram illustrating hierarchical clustering of metabolites that changed with exercise.
  • Table S1. Metabolites that change within plasma in response to exercise in the entire exercise tolerance test cohort (n = 70; P < 0.05).
  • Table S2. Clinical characteristics of subjects with exercise-induced myocardial ischemia and control subjects without inducible ischemia.
  • Table S3. Differential changes in metabolite concentrations per MET achieved during exercise tolerance testing among more and less fit individuals.
  • Table S4. Clinical characteristics of Framingham Heart Study participants in whom metabolites were measured.
  • Table S5. Relation between plasma metabolite concentrations and resting heart rate in Framingham Heart Study participants.
  • References

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