Supplementary Material

Supplementary Material for:

Development of Personalized Tumor Biomarkers Using Massively
Parallel Sequencing

Rebecca J. Leary, Isaac Kinde, Frank Diehl, Kerstin Schmidt, Chris Clouser, Cisilya Duncan, Alena Antipova, Clarence Lee, Kevin McKernan, Francisco M. De La Vega, Kenneth W. Kinzler, Bert Vogelstein, Luis A. Diaz Jr., Victor E. Velculescu*

*To whom correspondence should be addressed. E-mail: velculescu{at}

Published 24 February 2010, Sci. Transl. Med. 2, 20ra14 (2010)
DOI: 10.1126/scitranslmed.3000702

This PDF file includes:

  • Table S1. Comparison of SOLiD sequencing, Illumina SNP arrays, and Digital Karyotyping for analysis of copy number alterations.
  • Table S2. Putative copy number alterations identified by SOLiD sequencing in Co84 that were not identified by Illumina SNP arrays or Digital Karyotyping.
  • Table S3. Confirmed somatic rearrangements in breast and colorectal cancer samples.
  • Fig. S1. Flow chart of approach used to identify rearranged sequences.
  • Fig. S2. Comparison of Digital Karyotyping, Illumina SNP array, and SOLiD sequencing results on chromosome 8.

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