Research ArticleNeuroscience
Hippocampal extracellular matrix alterations contribute to cognitive impairment associated with a chronic depressive-like state in rats
- Danai Riga1,
- Ioannis Kramvis2,*,
- Maija K. Koskinen1,*,
- Pieter van Bokhoven1,*,
- Johanneke E. van der Harst3,4,
- Tim S. Heistek2,
- A. Jaap Timmerman2,
- Pim van Nierop1,
- Roel C. van der Schors1,
- Anton W. Pieneman1,
- Anouk de Weger1,
- Yvar van Mourik5,
- Anton N. M. Schoffelmeer5,
- Huib D. Mansvelder2,
- Rhiannon M. Meredith2,
- Witte J. G. Hoogendijk6,
- August B. Smit1,† and
- Sabine Spijker1,†,‡
- 1Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam, Netherlands.
- 2Department of Integrative Neurophysiology, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam, Netherlands.
- 3Department of Biology, Institute of Environmental Biology, Animal Ecology group Biology, Utrecht University, Utrecht, Netherlands.
- 4Department of Cognitive Neuroscience, Radboud University Medical Center, Nijmegen, Netherlands.
- 5Department of Anatomy and Neurosciences, Amsterdam Neuroscience, VU Medical Center, Amsterdam, Netherlands.
- 6Department of Psychiatry, Erasmus Medical Center, Rotterdam, Netherlands.
- ↵‡Corresponding author. Email: s.spijker{at}vu.nl
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Science Translational Medicine 20 Dec 2017:
Vol. 9, Issue 421, eaai8753
DOI: 10.1126/scitranslmed.aai8753
Vol. 9, Issue 421, eaai8753
DOI: 10.1126/scitranslmed.aai8753
Danai Riga
Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam, Netherlands.
Ioannis Kramvis
Department of Integrative Neurophysiology, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam, Netherlands.
Maija K. Koskinen
Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam, Netherlands.
Pieter van Bokhoven
Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam, Netherlands.
Johanneke E. van der Harst
Department of Biology, Institute of Environmental Biology, Animal Ecology group Biology, Utrecht University, Utrecht, Netherlands.Department of Cognitive Neuroscience, Radboud University Medical Center, Nijmegen, Netherlands.
Tim S. Heistek
Department of Integrative Neurophysiology, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam, Netherlands.
A. Jaap Timmerman
Department of Integrative Neurophysiology, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam, Netherlands.
Pim van Nierop
Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam, Netherlands.
Roel C. van der Schors
Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam, Netherlands.
Anton W. Pieneman
Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam, Netherlands.
Anouk de Weger
Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam, Netherlands.
Yvar van Mourik
Department of Anatomy and Neurosciences, Amsterdam Neuroscience, VU Medical Center, Amsterdam, Netherlands.
Anton N. M. Schoffelmeer
Department of Anatomy and Neurosciences, Amsterdam Neuroscience, VU Medical Center, Amsterdam, Netherlands.
Huib D. Mansvelder
Department of Integrative Neurophysiology, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam, Netherlands.
Rhiannon M. Meredith
Department of Integrative Neurophysiology, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam, Netherlands.
Witte J. G. Hoogendijk
Department of Psychiatry, Erasmus Medical Center, Rotterdam, Netherlands.
August B. Smit
Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam, Netherlands.
Sabine Spijker
Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam, Netherlands.
