Research ArticleNeurodegeneration

A human microglia-like cellular model for assessing the effects of neurodegenerative disease gene variants

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Science Translational Medicine  20 Dec 2017:
Vol. 9, Issue 421, eaai7635
DOI: 10.1126/scitranslmed.aai7635

Article Information

vol. 9 no. 421

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History: 
  • Received for publication August 8, 2016
  • Resubmitted April 12, 2017
  • Accepted for publication August 18, 2017
  • .

Author Information

  1. Katie J. Ryan1,2,3,4,
  2. Charles C. White1,2,4,
  3. Kruti Patel1,2,3,4,
  4. Jishu Xu1,2,4,
  5. Marta Olah4,5,
  6. Joseph M. Replogle1,2,3,4,*,
  7. Michael Frangieh1,2,4,
  8. Maria Cimpean1,2,4,,
  9. Phoebe Winn1,2,4,
  10. Allison McHenry1,2,4,
  11. Belinda J. Kaskow1,2,3,4,
  12. Gail Chan1,2,3,4,
  13. Nicole Cuerdon1,2,3,4,
  14. David A. Bennett6,
  15. Justin D. Boyd1,3,
  16. Jaime Imitola7,
  17. Wassim Elyaman4,5,
  18. Philip L. De Jager4,5 and
  19. Elizabeth M. Bradshaw4,5,
  1. 1Ann Romney Center for Neurologic Diseases, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA.
  2. 2Program in Translational NeuroPsychiatric Genomics, Institute for the Neurosciences, Departments of Neurology and Psychiatry, Brigham and Women’s Hospital, 77 Avenue Louis Pasteur, NRB168, Boston, MA 02115, USA.
  3. 3Harvard Medical School, Boston, MA 02115, USA.
  4. 4Program in Medical and Population Genetics, Broad Institute, 7 Cambridge Center, Cambridge, MA 02142, USA.
  5. 5Center for Translational and Computational Neuroimmunology, Department of Neurology, Columbia University Medical Center, 630 West 168th Street, New York, NY 10032, USA.
  6. 6Rush Alzheimer’s Disease Center, Rush University Medical Center, Chicago, IL 60612, USA.
  7. 7Laboratory of Neural Stem Cells and Functional Neurogenetics, Departments of Neurology and Neuroscience, The Ohio State University College of Medicine, 333 West 10th Avenue, Columbus, OH 43210, USA.
  1. Corresponding author. Email: emb2280{at}cumc.columbia.edu
  • * Present address: Medical Scientist Training Program, University of California, San Francisco, San Francisco, CA 94143, USA.

  • Present address: Division of Biology and Biomedical Sciences, Graduate Program in Immunology, Washington University in St. Louis, One Brookings Drive, St. Louis, MO 63130, USA.

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