Contents
20 December 2017
Vol 9, Issue 421
Vol 9, Issue 421
Research Articles
- A human microglia-like cellular model for assessing the effects of neurodegenerative disease gene variants
A microglial-like cellular model can be used to identify functional consequences of genetic variants associated with neurodegenerative disease.
- Enhanced human hematopoietic stem and progenitor cell engraftment by blocking donor T cell–mediated TNFα signaling
Blocking posttransplantation donor T cell–mediated inflammation enhances stem cell survival and accelerates blood cell reconstitution rates.
- Human ESC–derived retinal epithelial cell sheets potentiate rescue of photoreceptor cell loss in rats with retinal degeneration
Human ESC–derived retinal pigment epithelial cell sheets are more effective than cell suspensions at rescuing photoreceptor cell loss in rats with retinal dystrophy.
- Hippocampal extracellular matrix alterations contribute to cognitive impairment associated with a chronic depressive-like state in rats
Alterations in the hippocampal extracellular matrix contribute to cognitive deficits in rats exhibiting a chronic depressive-like state after exposure to social defeat–induced persistent stress.
Report
- Vaccination of dogs in an African city interrupts rabies transmission and reduces human exposure
A citywide dog vaccination effort in Chad reduced the local spread of rabies from dogs to humans.
Editors' Choice
- A homestay for your heart
Heart-injectable hydrogels containing microRNA promote cardiomyocyte proliferation in mice after myocardial infarction.
- Statins are skin safe, now go innovate!
Epidemiological data demonstrate no overall increased risk of skin cancer with statin use.
- Stress signal ACTs to hinder sleep in PTSD
Adrenocorticotropic hormone (ACTH) modulation is associated with sleep disturbances in individuals with posttraumatic stress disorder.
- Personalized medicine finds the MAPK for breast cancer
Whole-exome sequencing and RNA-seq on a mouse model of triple-negative breast cancer reveal actionable therapeutic targets for precision medicine guided treatment.
Erratum
About The Cover
ONLINE COVER Stopping Rabies in Its Tracks. Pictured is a Chadian boy after vaccination of his dog against rabies in N'Djaména in October, 2013. Zoonotic rabies still persists in certain areas of Africa and Asia and constitutes a serious public health threat. Two consecutive, large-scale vaccination campaigns previously conducted in N'Djaména, the capital city of Chad, resulted in vaccination of a majority of locally owned dogs free of charge. Using a viral transmission model fitted to data collected from both vaccination operations, Zinsstag et al. calculated that the two vaccination campaigns were effective in reducing the regional dog-to-dog and dog-to-human transmission of rabies. [CREDIT: CHRISTIAN HEUSS, SWISS TPH]
