Research ArticleHIV

Effect of population viral load on prospective HIV incidence in a hyperendemic rural African community

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Science Translational Medicine  13 Dec 2017:
Vol. 9, Issue 420, eaam8012
DOI: 10.1126/scitranslmed.aam8012

Status is not everything

Many parameters are examined to try to understand HIV transmission in endemic areas. Tanser et al. use longitudinal population-based data from rural South Africa to show that population viral load indices incorporating geographical location and local HIV prevalence can be used to infer HIV transmission potential. Their data demonstrate that accounting for HIV-negative individuals in calculations and transmission models is important for appropriate interpretations. Their findings could be helpful in guiding prevention intervention strategies in hyperendemic settings.

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