Research ArticleFibrosis
Targeted apoptosis of myofibroblasts with the BH3 mimetic ABT-263 reverses established fibrosis
- View ORCID ProfileDavid Lagares1,*,
- View ORCID ProfileAlba Santos1,†,
- View ORCID ProfilePaula E. Grasberger1,†,
- View ORCID ProfileFei Liu2,
- View ORCID ProfileClemens K. Probst1,
- View ORCID ProfileRod A. Rahimi1,
- Norihiko Sakai1,3,
- Tobias Kuehl1,
- View ORCID ProfileJeremy Ryan4,
- Patrick Bhola4,
- Joan Montero4,
- View ORCID ProfileMohit Kapoor5,
- View ORCID ProfileMurray Baron6,
- Xaralabos Varelas7,
- View ORCID ProfileDaniel J. Tschumperlin2,8,
- Anthony Letai4 and
- Andrew M. Tager1,‡
- 1Fibrosis Research Center and Center for Immunology and Inflammatory Diseases, Division of Pulmonary and Critical Care Medicine, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.
- 2Molecular and Integrative Physiological Sciences Program, Harvard T. H. Chan School of Public Health, Boston, MA 02115, USA.
- 3Division of Nephrology and Division of Blood Purification, Kanazawa University Hospital, Kanazawa, Japan.
- 4Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA.
- 5Krembil Research Institute, University Health Network and Department of Surgery and Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada.
- 6Jewish General Hospital, McGill University, Montreal, Quebec, Canada.
- 7Department of Biochemistry, Boston University School of Medicine, Boston, MA 02118, USA.
- 8Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN 55905, USA.
- ↵*Corresponding author. Email: dlagares{at}mgh.harvard.edu
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Science Translational Medicine 13 Dec 2017:
Vol. 9, Issue 420, eaal3765
DOI: 10.1126/scitranslmed.aal3765
Vol. 9, Issue 420, eaal3765
DOI: 10.1126/scitranslmed.aal3765
David Lagares
1Fibrosis Research Center and Center for Immunology and Inflammatory Diseases, Division of Pulmonary and Critical Care Medicine, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.
Alba Santos
1Fibrosis Research Center and Center for Immunology and Inflammatory Diseases, Division of Pulmonary and Critical Care Medicine, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.
Paula E. Grasberger
1Fibrosis Research Center and Center for Immunology and Inflammatory Diseases, Division of Pulmonary and Critical Care Medicine, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.
Fei Liu
2Molecular and Integrative Physiological Sciences Program, Harvard T. H. Chan School of Public Health, Boston, MA 02115, USA.
Clemens K. Probst
1Fibrosis Research Center and Center for Immunology and Inflammatory Diseases, Division of Pulmonary and Critical Care Medicine, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.
Rod A. Rahimi
1Fibrosis Research Center and Center for Immunology and Inflammatory Diseases, Division of Pulmonary and Critical Care Medicine, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.
Norihiko Sakai
1Fibrosis Research Center and Center for Immunology and Inflammatory Diseases, Division of Pulmonary and Critical Care Medicine, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.
3Division of Nephrology and Division of Blood Purification, Kanazawa University Hospital, Kanazawa, Japan.
Tobias Kuehl
1Fibrosis Research Center and Center for Immunology and Inflammatory Diseases, Division of Pulmonary and Critical Care Medicine, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.
Jeremy Ryan
4Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA.
Patrick Bhola
4Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA.
Joan Montero
4Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA.
Mohit Kapoor
5Krembil Research Institute, University Health Network and Department of Surgery and Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada.
Murray Baron
6Jewish General Hospital, McGill University, Montreal, Quebec, Canada.
Xaralabos Varelas
7Department of Biochemistry, Boston University School of Medicine, Boston, MA 02118, USA.
Daniel J. Tschumperlin
2Molecular and Integrative Physiological Sciences Program, Harvard T. H. Chan School of Public Health, Boston, MA 02115, USA.
8Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN 55905, USA.
Anthony Letai
4Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA.
Andrew M. Tager
1Fibrosis Research Center and Center for Immunology and Inflammatory Diseases, Division of Pulmonary and Critical Care Medicine, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.
