Research ArticleFibrosis
Targeted apoptosis of myofibroblasts with the BH3 mimetic ABT-263 reverses established fibrosis
- David Lagares1,*,
- Alba Santos1,†,
- Paula E. Grasberger1,†,
- Fei Liu2,
- Clemens K. Probst1,
- Rod A. Rahimi1,
- Norihiko Sakai1,3,
- Tobias Kuehl1,
- Jeremy Ryan4,
- Patrick Bhola4,
- Joan Montero4,
- Mohit Kapoor5,
- Murray Baron6,
- Xaralabos Varelas7,
- Daniel J. Tschumperlin2,8,
- Anthony Letai4 and
- Andrew M. Tager1,‡
- 1Fibrosis Research Center and Center for Immunology and Inflammatory Diseases, Division of Pulmonary and Critical Care Medicine, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.
- 2Molecular and Integrative Physiological Sciences Program, Harvard T. H. Chan School of Public Health, Boston, MA 02115, USA.
- 3Division of Nephrology and Division of Blood Purification, Kanazawa University Hospital, Kanazawa, Japan.
- 4Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA.
- 5Krembil Research Institute, University Health Network and Department of Surgery and Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada.
- 6Jewish General Hospital, McGill University, Montreal, Quebec, Canada.
- 7Department of Biochemistry, Boston University School of Medicine, Boston, MA 02118, USA.
- 8Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN 55905, USA.
- ↵*Corresponding author. Email: dlagares{at}mgh.harvard.edu
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Science Translational Medicine 13 Dec 2017:
Vol. 9, Issue 420, eaal3765
DOI: 10.1126/scitranslmed.aal3765
Vol. 9, Issue 420, eaal3765
DOI: 10.1126/scitranslmed.aal3765
David Lagares
Fibrosis Research Center and Center for Immunology and Inflammatory Diseases, Division of Pulmonary and Critical Care Medicine, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.
Alba Santos
Fibrosis Research Center and Center for Immunology and Inflammatory Diseases, Division of Pulmonary and Critical Care Medicine, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.
Paula E. Grasberger
Fibrosis Research Center and Center for Immunology and Inflammatory Diseases, Division of Pulmonary and Critical Care Medicine, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.
Fei Liu
Molecular and Integrative Physiological Sciences Program, Harvard T. H. Chan School of Public Health, Boston, MA 02115, USA.
Clemens K. Probst
Fibrosis Research Center and Center for Immunology and Inflammatory Diseases, Division of Pulmonary and Critical Care Medicine, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.
Rod A. Rahimi
Fibrosis Research Center and Center for Immunology and Inflammatory Diseases, Division of Pulmonary and Critical Care Medicine, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.
Norihiko Sakai
Fibrosis Research Center and Center for Immunology and Inflammatory Diseases, Division of Pulmonary and Critical Care Medicine, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.Division of Nephrology and Division of Blood Purification, Kanazawa University Hospital, Kanazawa, Japan.
Tobias Kuehl
Fibrosis Research Center and Center for Immunology and Inflammatory Diseases, Division of Pulmonary and Critical Care Medicine, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.
Jeremy Ryan
Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA.
Patrick Bhola
Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA.
Joan Montero
Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA.
Mohit Kapoor
Krembil Research Institute, University Health Network and Department of Surgery and Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada.
Murray Baron
Jewish General Hospital, McGill University, Montreal, Quebec, Canada.
Xaralabos Varelas
Department of Biochemistry, Boston University School of Medicine, Boston, MA 02118, USA.
Daniel J. Tschumperlin
Molecular and Integrative Physiological Sciences Program, Harvard T. H. Chan School of Public Health, Boston, MA 02115, USA.Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN 55905, USA.
Anthony Letai
Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA.
Andrew M. Tager
Fibrosis Research Center and Center for Immunology and Inflammatory Diseases, Division of Pulmonary and Critical Care Medicine, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.
