Research ArticleFibrosis

Targeted apoptosis of myofibroblasts with the BH3 mimetic ABT-263 reverses established fibrosis

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Science Translational Medicine  13 Dec 2017:
Vol. 9, Issue 420, eaal3765
DOI: 10.1126/scitranslmed.aal3765

Article Information

vol. 9 no. 420

PubMed: 
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History: 
  • Received for publication November 15, 2016
  • Resubmitted July 28, 2017
  • Accepted for publication October 30, 2017
  • .

Author Information

  1. David Lagares1,*,
  2. Alba Santos1,,
  3. Paula E. Grasberger1,,
  4. Fei Liu2,
  5. Clemens K. Probst1,
  6. Rod A. Rahimi1,
  7. Norihiko Sakai1,3,
  8. Tobias Kuehl1,
  9. Jeremy Ryan4,
  10. Patrick Bhola4,
  11. Joan Montero4,
  12. Mohit Kapoor5,
  13. Murray Baron6,
  14. Xaralabos Varelas7,
  15. Daniel J. Tschumperlin2,8,
  16. Anthony Letai4 and
  17. Andrew M. Tager1,
  1. 1Fibrosis Research Center and Center for Immunology and Inflammatory Diseases, Division of Pulmonary and Critical Care Medicine, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.
  2. 2Molecular and Integrative Physiological Sciences Program, Harvard T. H. Chan School of Public Health, Boston, MA 02115, USA.
  3. 3Division of Nephrology and Division of Blood Purification, Kanazawa University Hospital, Kanazawa, Japan.
  4. 4Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA.
  5. 5Krembil Research Institute, University Health Network and Department of Surgery and Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada.
  6. 6Jewish General Hospital, McGill University, Montreal, Quebec, Canada.
  7. 7Department of Biochemistry, Boston University School of Medicine, Boston, MA 02118, USA.
  8. 8Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN 55905, USA.
  1. *Corresponding author. Email: dlagares{at}mgh.harvard.edu
    • These authors contributed equally to this work.

    • Deceased.

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