Research ArticleMultiple Sclerosis
BCAS1 expression defines a population of early myelinating oligodendrocytes in multiple sclerosis lesions
- Maryam K. Fard1,*,†,
- Franziska van der Meer2,*,
- Paula Sánchez1,
- Ludovico Cantuti-Castelvetri1,
- Sunit Mandad3,4,
- Sarah Jäkel5,
- Eugenio F. Fornasiero3,
- Sebastian Schmitt1,
- Marc Ehrlich6,7,
- Laura Starost6,7,
- Tanja Kuhlmann7,
- Christina Sergiou2,
- Verena Schultz2,
- Claudia Wrzos2,
- Wolfgang Brück2,
- Henning Urlaub4,8,
- Leda Dimou5,9,10,
- Christine Stadelmann2,†,‡ and
- Mikael Simons1,10,11,12,†,‡
- 1Max Planck Institute for Experimental Medicine, 37075 Göttingen, Germany.
- 2Department of Neuropathology, University of Göttingen Medical Center, 37075 Göttingen, Germany.
- 3Department of Neuro- and Sensory Physiology, University of Göttingen Medical Center, 37073 Göttingen, Germany.
- 4Max Planck Institute for Biophysical Chemistry, 37073 Göttingen, Germany.
- 5Department of Physiological Genomics, BioMedical Center, Ludwig-Maximilians-Universität München, Munich, Germany.
- 6Institute of Neuropathology, University Hospital Münster, 48149 Münster, Germany.
- 7Department of Cell and Developmental Biology, Max Planck Institute for Molecular Biomedicine, 48149 Münster, Germany.
- 8Bioanalytical Mass Spectrometry Group, Department of Clinical Chemistry, University of Göttingen Medical Center, Robert Koch Straße 40, 37075 Göttingen, Germany.
- 9Molecular and Translational Neuroscience, Department of Neurology, Medical Faculty, Ulm University, 89081 Ulm, Germany.
- 10Munich Cluster for Systems Neurology (SyNergy), 81377 Munich, Germany.
- 11Institute of Neuronal Cell Biology, Technical University of Munich, 80805 Munich, Germany.
- 12German Center for Neurodegenerative Diseases (DZNE), 6250 Munich, Germany.
- ↵†Corresponding author. Email: cstadelmann{at}med.uni-goettingen.de (C.S.); khojasteh{at}em.mpg.de (M.K.F.); msimons{at}gwdg.de (M.S.)
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Science Translational Medicine 06 Dec 2017:
Vol. 9, Issue 419, eaam7816
DOI: 10.1126/scitranslmed.aam7816
