Research ArticleISCHEMIA/REPERFUSION INJURY

Irisin protects mitochondria function during pulmonary ischemia/reperfusion injury

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Science Translational Medicine  29 Nov 2017:
Vol. 9, Issue 418, eaao6298
DOI: 10.1126/scitranslmed.aao6298

Protecting the lungs with irisin

Limb remote ischemic preconditioning, or subjecting a limb to temporary periods of brief ischemia, is a method that can be used to protect the lungs from ischemia/reperfusion damage due to an expected stressor such as surgery. Chen et al. investigated the mechanism by which this occurs and determined that remote ischemic preconditioning releases irisin, a myokine that targets mitochondria and blocks some of the deleterious effects of oxidative stress. The authors showed that this can occur naturally, as when infants with neonatal respiratory distress syndrome show transfer of endogenous irisin from the circulation into the lungs, or it can be induced therapeutically, as the authors demonstrated by treating mouse models with exogenous irisin, which protected their lungs from ischemia/reperfusion injury.

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