Vasopressin stimulates the proliferation and differentiation of red blood cell precursors and improves recovery from anemia

Balázs Mayer; Krisztián Németh; Miklós Krepuska; Vamsee D. Myneni; Dragan Maric; John F. Tisdale; Matthew M. Hsieh; Naoya Uchida; Heon-Jin Lee; Michael J. Nemeth; Kenn Holmbeck; Constance Tom Noguchi; Heather Rogers; Soumyadeep Dey; Arne Hansen; Jeffrey Hong; Ian Chow; Sharon Key; Ildikó Szalayova; Jerome Pagani; Károly Markó; Ian McClain-Caldwell; Lynn Vitale-Cross; W. Scott Young; Michael J. Brownstein; Éva Mezey

doi:10.1126/scitranslmed.aao1632

Research ArticleANEMIA

Vasopressin stimulates the proliferation and differentiation of red blood cell precursors and improves recovery from anemia

View ORCID ProfileBalázs Mayer¹,*,
Krisztián Németh¹,*,
View ORCID ProfileMiklós Krepuska¹,*,
View ORCID ProfileVamsee D. Myneni¹,*,
Dragan Maric²,
John F. Tisdale³,
View ORCID ProfileMatthew M. Hsieh³,
Naoya Uchida³,
View ORCID ProfileHeon-Jin Lee⁴,⁵,
View ORCID ProfileMichael J. Nemeth⁶,
View ORCID ProfileKenn Holmbeck¹,
View ORCID ProfileConstance Tom Noguchi⁷,
Heather Rogers⁷,
Soumyadeep Dey⁷,
Arne Hansen¹,
View ORCID ProfileJeffrey Hong¹,
Ian Chow¹,
Sharon Key¹,
View ORCID ProfileIldikó Szalayova¹,
Jerome Pagani⁴,
Károly Markó¹,
Ian McClain-Caldwell¹,
View ORCID ProfileLynn Vitale-Cross¹,
View ORCID ProfileW. Scott Young⁴,
Michael J. Brownstein⁸ and
View ORCID ProfileÉva Mezey¹,†

¹Adult Stem Cell Section, Craniofacial and Skeletal Diseases Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health (NIH), Bethesda, MD 20892, USA.
²National Institute of Neurological Disorders and Stroke, NIH, Bethesda, MD 20892, USA.
³Molecular and Clinical Hematology Branch, National Heart, Lung, and Blood Institute, NIH, Bethesda, MD 20892, USA.
⁴Section on Neural Gene Expression, National Institute of Mental Health, NIH, Bethesda, MD 20892, USA.
⁵Department of Oral Microbiology and Immunology, School of Dentistry, Kyungpook National University, Daegu, Korea.
⁶Department of Immunology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA.
⁷Molecular Medicine Branch, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, MD 20892, USA.
⁸Azevan Pharmaceutical, Bethlehem, PA 18015, USA.

↵†Corresponding author. Email: mezeye{at}mail.nih.gov

↵* These authors contributed equally to this work.

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Science Translational Medicine 29 Nov 2017:
Vol. 9, Issue 418, eaao1632
DOI: 10.1126/scitranslmed.aao1632

Balázs Mayer

1Adult Stem Cell Section, Craniofacial and Skeletal Diseases Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health (NIH), Bethesda, MD 20892, USA.

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Krisztián Németh

1Adult Stem Cell Section, Craniofacial and Skeletal Diseases Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health (NIH), Bethesda, MD 20892, USA.

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Miklós Krepuska

1Adult Stem Cell Section, Craniofacial and Skeletal Diseases Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health (NIH), Bethesda, MD 20892, USA.

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Vamsee D. Myneni

1Adult Stem Cell Section, Craniofacial and Skeletal Diseases Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health (NIH), Bethesda, MD 20892, USA.

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Dragan Maric

2National Institute of Neurological Disorders and Stroke, NIH, Bethesda, MD 20892, USA.

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John F. Tisdale

3Molecular and Clinical Hematology Branch, National Heart, Lung, and Blood Institute, NIH, Bethesda, MD 20892, USA.

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Matthew M. Hsieh

3Molecular and Clinical Hematology Branch, National Heart, Lung, and Blood Institute, NIH, Bethesda, MD 20892, USA.

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Naoya Uchida

3Molecular and Clinical Hematology Branch, National Heart, Lung, and Blood Institute, NIH, Bethesda, MD 20892, USA.

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Heon-Jin Lee

4Section on Neural Gene Expression, National Institute of Mental Health, NIH, Bethesda, MD 20892, USA.

5Department of Oral Microbiology and Immunology, School of Dentistry, Kyungpook National University, Daegu, Korea.

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Michael J. Nemeth

6Department of Immunology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA.

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Kenn Holmbeck

1Adult Stem Cell Section, Craniofacial and Skeletal Diseases Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health (NIH), Bethesda, MD 20892, USA.

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Constance Tom Noguchi

7Molecular Medicine Branch, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, MD 20892, USA.

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Heather Rogers

7Molecular Medicine Branch, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, MD 20892, USA.

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Soumyadeep Dey

7Molecular Medicine Branch, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, MD 20892, USA.

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Arne Hansen

1Adult Stem Cell Section, Craniofacial and Skeletal Diseases Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health (NIH), Bethesda, MD 20892, USA.

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Jeffrey Hong

1Adult Stem Cell Section, Craniofacial and Skeletal Diseases Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health (NIH), Bethesda, MD 20892, USA.

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Ian Chow

1Adult Stem Cell Section, Craniofacial and Skeletal Diseases Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health (NIH), Bethesda, MD 20892, USA.

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Sharon Key

1Adult Stem Cell Section, Craniofacial and Skeletal Diseases Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health (NIH), Bethesda, MD 20892, USA.

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Ildikó Szalayova

1Adult Stem Cell Section, Craniofacial and Skeletal Diseases Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health (NIH), Bethesda, MD 20892, USA.

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Jerome Pagani

4Section on Neural Gene Expression, National Institute of Mental Health, NIH, Bethesda, MD 20892, USA.

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Károly Markó

1Adult Stem Cell Section, Craniofacial and Skeletal Diseases Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health (NIH), Bethesda, MD 20892, USA.

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Ian McClain-Caldwell

1Adult Stem Cell Section, Craniofacial and Skeletal Diseases Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health (NIH), Bethesda, MD 20892, USA.

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Lynn Vitale-Cross

1Adult Stem Cell Section, Craniofacial and Skeletal Diseases Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health (NIH), Bethesda, MD 20892, USA.

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W. Scott Young

4Section on Neural Gene Expression, National Institute of Mental Health, NIH, Bethesda, MD 20892, USA.

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Michael J. Brownstein

8Azevan Pharmaceutical, Bethlehem, PA 18015, USA.

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Éva Mezey

1Adult Stem Cell Section, Craniofacial and Skeletal Diseases Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health (NIH), Bethesda, MD 20892, USA.

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For correspondence: mezeye@mail.nih.gov

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Vasopressin stimulates the proliferation and differentiation of red blood cell precursors and improves recovery from anemia

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