Research ArticleOrgan Transplantation

Nanoparticle targeting to the endothelium during normothermic machine perfusion of human kidneys

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Science Translational Medicine  29 Nov 2017:
Vol. 9, Issue 418, eaam6764
DOI: 10.1126/scitranslmed.aam6764

Particle perfusion for organ transplant

Ischemia-reperfusion injury, which occurs when a tissue or organ is temporarily cut off from blood flow, is a major issue limiting organ viability for transplantation. Tietjan et al. devised a way to target the injury-sensitive endothelium of organs during ex vivo perfusion. Using nanoparticles conjugated to an antibody targeting a protein expressed on endothelial cells, the authors demonstrated that they could perfuse human kidneys and that nanoparticles accumulated in kidney endothelial cells. In addition to expanding the pool of viable organs for transplant, this approach could potentially be used to deliver targeted therapies to organs during ex vivo perfusion rather than treating the transplant recipient systemically.

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