Contents
29 November 2017
Vol 9, Issue 418
Vol 9, Issue 418
Research Articles
- Nanoparticle targeting to the endothelium during normothermic machine perfusion of human kidneys
Anti-CD31 antibody conjugation can enhance nanoparticle accumulation in the vascular endothelium of human kidneys during ex vivo normothermic machine perfusion.
- Single-cut genome editing restores dystrophin expression in a new mouse model of muscular dystrophy
Single-cut correction of a dystrophin gene mutation with CRISPR/Cas9 restored dystrophin expression in skeletal and cardiac muscles in a mouse model of Duchenne muscular dystrophy.
- Irisin protects mitochondria function during pulmonary ischemia/reperfusion injury
Irisin protects against ischemia/reperfusion injury to the lung by improving mitochondrial function.
- Rescue of Pompe disease in mice by AAV-mediated liver delivery of secretable acid α-glucosidase
Liver delivery of engineered GAA transgenes to mice with Pompe disease rescued glycogen accumulation in multiple tissues.
Editors' Choice
- To grow or not to grow: Postantibiotic effect is the question
Temporary inhibition of Escherichia coli growth in vitro after antibiotic administration is proportional to total antibiotic quantity.
- A scar-y movie, starring IL-11
IL-11 is found to be a critical mediator of TGFβ1-induced scarring and fibrosis in the heart and kidney.
- Feel the burn to improve cognition
Increased brain lactate uptake is related to improved executive function following high-intensity interval exercise.
- S. aureus induces IL-36 to start the itch
Epicutaneous exposure to Staphylococcus aureus phenol-soluble modulin alpha peptides facilitates IL-36–dependent skin inflammation.
About The Cover
ONLINE COVER Particles for Perfusion. Here we see nanoparticles (red and orange) among cells (blue, nuclear stain) within glomeruli isolated from human kidneys. Tietjen and colleagues used an antibody to target nanoparticles to the endothelium of the kidney during ex vivo organ perfusion. Nanoparticles accumulated within the glomerular and interstitial endothelial cells. Nanoparticles can be used to deliver drugs, which could potentially prevent ischemia/reperfusion injury in these cells. Using targeted nanoparticles during ex vivo perfusion could help expand the pool of viable donor organs for transplant and delivering therapies to donor organs prior to transplant could be an alternative to systemically treating the transplant recipient. [CREDIT: TIETJEN ET AL./SCIENCE TRANSLATIONAL MEDICINE]
