29 November 2017
Vol 9, Issue 418

About The Cover

Cover image expansion

ONLINE COVER Particles for Perfusion. Here we see nanoparticles (red and orange) among cells (blue, nuclear stain) within glomeruli isolated from human kidneys. Tietjen and colleagues used an antibody to target nanoparticles to the endothelium of the kidney during ex vivo organ perfusion. Nanoparticles accumulated within the glomerular and interstitial endothelial cells. Nanoparticles can be used to deliver drugs, which could potentially prevent ischemia/reperfusion injury in these cells. Using targeted nanoparticles during ex vivo perfusion could help expand the pool of viable donor organs for transplant and delivering therapies to donor organs prior to transplant could be an alternative to systemically treating the transplant recipient. [CREDIT: TIETJEN ET AL./SCIENCE TRANSLATIONAL MEDICINE]