Integrated genomic and interfacility patient-transfer data reveal the transmission pathways of multidrug-resistant Klebsiella pneumoniae in a regional outbreak

Evan S. Snitkin; Sarah Won; Ali Pirani; Zena Lapp; Robert A. Weinstein; Karen Lolans; Mary K. Hayden

doi:10.1126/scitranslmed.aan0093

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Integrated genomic and interfacility patient-transfer data reveal the transmission pathways of multidrug-resistant Klebsiella pneumoniae in a regional outbreak

View ORCID ProfileEvan S. Snitkin¹,²,*,
View ORCID ProfileSarah Won³,
View ORCID ProfileAli Pirani¹,²,
View ORCID ProfileZena Lapp⁴,
View ORCID ProfileRobert A. Weinstein³,⁵,
Karen Lolans⁶ and
View ORCID ProfileMary K. Hayden³,⁶,*

¹Department of Microbiology and Immunology, University of Michigan, Ann Arbor, MI 48109, USA.
²Division of Infectious Diseases, Department of Medicine, University of Michigan, Ann Arbor, MI 48109, USA.
³Division of Infectious Diseases, Department of Internal Medicine, Rush University Medical Center, Chicago, IL 60612, USA.
⁴Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI 48109, USA.
⁵Division of Infectious Diseases, Department of Medicine, Cook County Health and Hospitals System, Chicago, IL 60612, USA.
⁶Division of Clinical Microbiology, Department of Pathology, Rush University Medical Center, Chicago, IL 60612, USA.

↵*Corresponding author. Email: esnitkin{at}umich.edu (E.S.S.); mhayden{at}rush.edu (M.K.H.)

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Science Translational Medicine 22 Nov 2017:
Vol. 9, Issue 417, eaan0093
DOI: 10.1126/scitranslmed.aan0093

Evan S. Snitkin

1Department of Microbiology and Immunology, University of Michigan, Ann Arbor, MI 48109, USA.

2Division of Infectious Diseases, Department of Medicine, University of Michigan, Ann Arbor, MI 48109, USA.

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ORCID record for Evan S. Snitkin
For correspondence: esnitkin@umich.edu mhayden@rush.edu

Sarah Won

3Division of Infectious Diseases, Department of Internal Medicine, Rush University Medical Center, Chicago, IL 60612, USA.

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Ali Pirani

1Department of Microbiology and Immunology, University of Michigan, Ann Arbor, MI 48109, USA.

2Division of Infectious Diseases, Department of Medicine, University of Michigan, Ann Arbor, MI 48109, USA.

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Zena Lapp

4Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI 48109, USA.

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Robert A. Weinstein

3Division of Infectious Diseases, Department of Internal Medicine, Rush University Medical Center, Chicago, IL 60612, USA.

5Division of Infectious Diseases, Department of Medicine, Cook County Health and Hospitals System, Chicago, IL 60612, USA.

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Karen Lolans

6Division of Clinical Microbiology, Department of Pathology, Rush University Medical Center, Chicago, IL 60612, USA.

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Mary K. Hayden

3Division of Infectious Diseases, Department of Internal Medicine, Rush University Medical Center, Chicago, IL 60612, USA.

6Division of Clinical Microbiology, Department of Pathology, Rush University Medical Center, Chicago, IL 60612, USA.

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ORCID record for Mary K. Hayden
For correspondence: esnitkin@umich.edu mhayden@rush.edu

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Integrated genomic and interfacility patient-transfer data reveal the transmission pathways of multidrug-resistant Klebsiella pneumoniae in a regional outbreak

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