Research ArticleCOAGULATION
Targeting STUB1–tissue factor axis normalizes hyperthrombotic uremic phenotype without increasing bleeding risk
- View ORCID ProfileMoshe Shashar1,*,
- View ORCID ProfileMostafa E. Belghasem2,*,
- View ORCID ProfileShinobu Matsuura3,
- View ORCID ProfileJoshua Walker1,
- Sean Richards1,
- View ORCID ProfileFaisal Alousi1,
- View ORCID ProfileKeshab Rijal1,
- View ORCID ProfileVijaya B. Kolachalama3,
- Mercedes Balcells4,5,
- View ORCID ProfileMinami Odagi6,
- Kazuo Nagasawa6,
- View ORCID ProfileJoel M. Henderson2,
- View ORCID ProfileAmitabh Gautam7,
- Richard Rushmore8,
- Jean Francis1,
- Daniel Kirchhofer9,
- Kumaran Kolandaivelu4,10,
- View ORCID ProfileDavid H. Sherr11,
- View ORCID ProfileElazer R. Edelman4,10,
- Katya Ravid3 and
- View ORCID ProfileVipul C. Chitalia1,2,3,†
- 1Renal Section, Department of Medicine, Boston University School of Medicine, Boston, MA 02118, USA.
- 2Department of Pathology and Laboratory Medicine, Boston University School of Medicine, Boston, MA 02118, USA.
- 3Department of Medicine and Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, MA 02118, USA.
- 4Institute of Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
- 5Biological Engineering Department, Institut Químic de Sarrià, Universitat Ramon Llull, Barcelona 08017, Spain.
- 6Tokyo University of Agriculture and Technology, 2-24-16 Naka-cho, Koganei, Tokyo 184-8588, Japan.
- 7Department of Surgery, Boston University School of Medicine, Boston, MA 02118, USA.
- 8Department of Anatomy and Neurobiology, Boston University School of Medicine, Boston, MA 02118, USA.
- 9Department of Early Discovery and Biochemistry, Genentech Inc., South San Francisco, CA 94080, USA.
- 10Cardiovascular Division, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA.
- 11Department of Environmental Health, School of Public Health, Boston University School of Medicine, Boston, MA 02118, USA.
- ↵†Corresponding author. Email: vichital{at}bu.edu
↵* These authors contributed equally to this work.
See allHide authors and affiliations
Science Translational Medicine 22 Nov 2017:
Vol. 9, Issue 417, eaam8475
DOI: 10.1126/scitranslmed.aam8475
Vol. 9, Issue 417, eaam8475
DOI: 10.1126/scitranslmed.aam8475
Moshe Shashar
1Renal Section, Department of Medicine, Boston University School of Medicine, Boston, MA 02118, USA.
Mostafa E. Belghasem
2Department of Pathology and Laboratory Medicine, Boston University School of Medicine, Boston, MA 02118, USA.
Shinobu Matsuura
3Department of Medicine and Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, MA 02118, USA.
Joshua Walker
1Renal Section, Department of Medicine, Boston University School of Medicine, Boston, MA 02118, USA.
Sean Richards
1Renal Section, Department of Medicine, Boston University School of Medicine, Boston, MA 02118, USA.
Faisal Alousi
1Renal Section, Department of Medicine, Boston University School of Medicine, Boston, MA 02118, USA.
Keshab Rijal
1Renal Section, Department of Medicine, Boston University School of Medicine, Boston, MA 02118, USA.
Vijaya B. Kolachalama
3Department of Medicine and Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, MA 02118, USA.
Mercedes Balcells
4Institute of Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
5Biological Engineering Department, Institut Químic de Sarrià, Universitat Ramon Llull, Barcelona 08017, Spain.
Minami Odagi
6Tokyo University of Agriculture and Technology, 2-24-16 Naka-cho, Koganei, Tokyo 184-8588, Japan.
Kazuo Nagasawa
6Tokyo University of Agriculture and Technology, 2-24-16 Naka-cho, Koganei, Tokyo 184-8588, Japan.
Joel M. Henderson
2Department of Pathology and Laboratory Medicine, Boston University School of Medicine, Boston, MA 02118, USA.
Amitabh Gautam
7Department of Surgery, Boston University School of Medicine, Boston, MA 02118, USA.
Richard Rushmore
8Department of Anatomy and Neurobiology, Boston University School of Medicine, Boston, MA 02118, USA.
Jean Francis
1Renal Section, Department of Medicine, Boston University School of Medicine, Boston, MA 02118, USA.
Daniel Kirchhofer
9Department of Early Discovery and Biochemistry, Genentech Inc., South San Francisco, CA 94080, USA.
Kumaran Kolandaivelu
4Institute of Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
10Cardiovascular Division, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA.
David H. Sherr
11Department of Environmental Health, School of Public Health, Boston University School of Medicine, Boston, MA 02118, USA.
Elazer R. Edelman
4Institute of Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
10Cardiovascular Division, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA.
Katya Ravid
3Department of Medicine and Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, MA 02118, USA.
Vipul C. Chitalia
1Renal Section, Department of Medicine, Boston University School of Medicine, Boston, MA 02118, USA.
2Department of Pathology and Laboratory Medicine, Boston University School of Medicine, Boston, MA 02118, USA.
3Department of Medicine and Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, MA 02118, USA.
