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Targeting STUB1–tissue factor axis normalizes hyperthrombotic uremic phenotype without increasing bleeding risk

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Science Translational Medicine  22 Nov 2017:
Vol. 9, Issue 417, eaam8475
DOI: 10.1126/scitranslmed.aam8475

Article Information

vol. 9 no. 417

PubMed: 
Print ISSN: 
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History: 
  • Received for publication January 24, 2017
  • Resubmitted July 31, 2017
  • Accepted for publication October 4, 2017
  • .

Author Information

  1. Moshe Shashar1,*,
  2. Mostafa E. Belghasem2,*,
  3. Shinobu Matsuura3,
  4. Joshua Walker1,
  5. Sean Richards1,
  6. Faisal Alousi1,
  7. Keshab Rijal1,
  8. Vijaya B. Kolachalama3,
  9. Mercedes Balcells4,5,
  10. Minami Odagi6,
  11. Kazuo Nagasawa6,
  12. Joel M. Henderson2,
  13. Amitabh Gautam7,
  14. Richard Rushmore8,
  15. Jean Francis1,
  16. Daniel Kirchhofer9,
  17. Kumaran Kolandaivelu4,10,
  18. David H. Sherr11,
  19. Elazer R. Edelman4,10,
  20. Katya Ravid3 and
  21. Vipul C. Chitalia1,2,3,
  1. 1Renal Section, Department of Medicine, Boston University School of Medicine, Boston, MA 02118, USA.
  2. 2Department of Pathology and Laboratory Medicine, Boston University School of Medicine, Boston, MA 02118, USA.
  3. 3Department of Medicine and Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, MA 02118, USA.
  4. 4Institute of Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
  5. 5Biological Engineering Department, Institut Químic de Sarrià, Universitat Ramon Llull, Barcelona 08017, Spain.
  6. 6Tokyo University of Agriculture and Technology, 2-24-16 Naka-cho, Koganei, Tokyo 184-8588, Japan.
  7. 7Department of Surgery, Boston University School of Medicine, Boston, MA 02118, USA.
  8. 8Department of Anatomy and Neurobiology, Boston University School of Medicine, Boston, MA 02118, USA.
  9. 9Department of Early Discovery and Biochemistry, Genentech Inc., South San Francisco, CA 94080, USA.
  10. 10Cardiovascular Division, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA.
  11. 11Department of Environmental Health, School of Public Health, Boston University School of Medicine, Boston, MA 02118, USA.
  1. Corresponding author. Email: vichital{at}bu.edu
    • * These authors contributed equally to this work.

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