Research ArticlePrion Disease

Prion seeding activity and infectivity in skin samples from patients with sporadic Creutzfeldt-Jakob disease

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Science Translational Medicine  22 Nov 2017:
Vol. 9, Issue 417, eaam7785
DOI: 10.1126/scitranslmed.aam7785

Article Information

vol. 9 no. 417

PubMed: 
Print ISSN: 
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History: 
  • Received for publication January 16, 2017
  • Resubmitted April 4, 2017
  • Accepted for publication August 18, 2017

Author Information

  1. Christina D. Orrú1,*,
  2. Jue Yuan2,*,
  3. Brian S. Appleby2,3,4,*,
  4. Baiya Li2,5,*,
  5. Yu Li2,6,
  6. Dane Winner7,
  7. Zerui Wang2,8,
  8. Yi-An Zhan2,6,
  9. Mark Rodgers2,
  10. Jason Rarick2,
  11. Robert E. Wyza9,
  12. Tripti Joshi9,
  13. Gong-Xian Wang6,
  14. Mark L. Cohen2,
  15. Shulin Zhang2,
  16. Bradley R. Groveman1,
  17. Robert B. Petersen10,
  18. James W. Ironside11,
  19. Miguel E. Quiñones-Mateu2,7,
  20. Jiri G. Safar2,4,
  21. Qingzhong Kong2,3,4,12,,
  22. Byron Caughey1, and
  23. Wen-Quan Zou2,3,4,6,8,12,13,
  1. 1Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA.
  2. 2Department of Pathology, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA.
  3. 3Department of Neurology, University Hospitals Cleveland Medical Center, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA.
  4. 4National Prion Disease Pathology Surveillance Center, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA.
  5. 5Department of Otolaryngology, The First Affiliated Hospital of Xi’an Jiaotong University, Shaanxi Province, People’s Republic of China.
  6. 6First Affiliated Hospital, Nanchang University, Nanchang, Jiangxi Province, People’s Republic of China.
  7. 7University Hospital Translational Laboratory, University Hospitals Cleveland Medical Center, Cleveland, OH 44106, USA.
  8. 8Department of Neurology, First Hospital of Jilin University, Changchun, Jilin Province, People’s Republic of China.
  9. 9Human Tissue Procurement Facility, Comprehensive Cancer Center Tissue Resources Core, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA.
  10. 10Foundation Sciences, Central Michigan University College of Medicine, Mount Pleasant, MI 48859, USA.
  11. 11National CJD Research and Surveillance Unit, Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK.
  12. 12National Center for Regenerative Medicine, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA.
  13. 13State Key Laboratory for Infectious Disease Prevention and Control, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, People’s Republic of China.
  1. Corresponding author. Email: wxz6{at}case.edu (W.-Q.Z.); bcaughey{at}nih.gov (B.C.); qingzhong.kong{at}case.edu (Q.K.)
    • * These authors contributed equally to this work.

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