TCR engagement negatively affects CD8 but not CD4 CAR T cell expansion and leukemic clearance

Yinmeng Yang; M. Eric Kohler; Christopher D. Chien; Christopher T. Sauter; Elad Jacoby; Chunhua Yan; Ying Hu; Kelsey Wanhainen; Haiying Qin; Terry J. Fry

doi:10.1126/scitranslmed.aag1209

Research ArticleCancer

TCR engagement negatively affects CD8 but not CD4 CAR T cell expansion and leukemic clearance

View ORCID ProfileYinmeng Yang¹,²,
M. Eric Kohler¹,³,
View ORCID ProfileChristopher D. Chien¹,
View ORCID ProfileChristopher T. Sauter¹,
View ORCID ProfileElad Jacoby¹,
Chunhua Yan⁴,
Ying Hu⁴,
Kelsey Wanhainen¹,
View ORCID ProfileHaiying Qin¹ and
View ORCID ProfileTerry J. Fry¹,*

¹Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
²Lombardi Comprehensive Cancer Center, Department of Oncology, Georgetown University, Washington, DC 20057, USA.
³Departments of Pediatric Oncology and Pediatric Hematology, Johns Hopkins University, Baltimore, MD 21287, USA.
⁴Center for Biomedical Informatics and Information Technology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.

↵*Corresponding author. Email: fryt{at}mail.nih.gov

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Science Translational Medicine 22 Nov 2017:
Vol. 9, Issue 417, eaag1209
DOI: 10.1126/scitranslmed.aag1209

Yinmeng Yang

1Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.

2Lombardi Comprehensive Cancer Center, Department of Oncology, Georgetown University, Washington, DC 20057, USA.

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ORCID record for Yinmeng Yang

M. Eric Kohler

1Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.

3Departments of Pediatric Oncology and Pediatric Hematology, Johns Hopkins University, Baltimore, MD 21287, USA.

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Christopher D. Chien

1Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.

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ORCID record for Christopher D. Chien

Christopher T. Sauter

1Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.

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Elad Jacoby

1Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.

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Chunhua Yan

4Center for Biomedical Informatics and Information Technology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.

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Ying Hu

4Center for Biomedical Informatics and Information Technology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.

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Kelsey Wanhainen

1Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.

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Haiying Qin

1Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.

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Terry J. Fry

1Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.

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ORCID record for Terry J. Fry
For correspondence: fryt@mail.nih.gov

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TCR engagement negatively affects CD8 but not CD4 CAR T cell expansion and leukemic clearance

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