TCR engagement negatively affects CD8 but not CD4 CAR T cell expansion and leukemic clearance

Yinmeng Yang; M. Eric Kohler; Christopher D. Chien; Christopher T. Sauter; Elad Jacoby; Chunhua Yan; Ying Hu; Kelsey Wanhainen; Haiying Qin; Terry J. Fry

doi:10.1126/scitranslmed.aag1209

Research ArticleCancer

TCR engagement negatively affects CD8 but not CD4 CAR T cell expansion and leukemic clearance

Yinmeng Yang¹,²,
M. Eric Kohler¹,³,
Christopher D. Chien¹,
Christopher T. Sauter¹,
Elad Jacoby¹,
Chunhua Yan⁴,
Ying Hu⁴,
Kelsey Wanhainen¹,
Haiying Qin¹ and
Terry J. Fry¹,*

¹Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
²Lombardi Comprehensive Cancer Center, Department of Oncology, Georgetown University, Washington, DC 20057, USA.
³Departments of Pediatric Oncology and Pediatric Hematology, Johns Hopkins University, Baltimore, MD 21287, USA.
⁴Center for Biomedical Informatics and Information Technology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.

↵*Corresponding author. Email: fryt{at}mail.nih.gov

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Science Translational Medicine 22 Nov 2017:
Vol. 9, Issue 417, eaag1209
DOI: 10.1126/scitranslmed.aag1209

Yinmeng Yang

Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.Lombardi Comprehensive Cancer Center, Department of Oncology, Georgetown University, Washington, DC 20057, USA.

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M. Eric Kohler

Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.Departments of Pediatric Oncology and Pediatric Hematology, Johns Hopkins University, Baltimore, MD 21287, USA.

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Christopher D. Chien

Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.

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ORCID record for Christopher D. Chien

Christopher T. Sauter

Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.

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Elad Jacoby

Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.

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Chunhua Yan

Center for Biomedical Informatics and Information Technology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.

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Ying Hu

Center for Biomedical Informatics and Information Technology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.

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Kelsey Wanhainen

Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.

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Haiying Qin

Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.

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Terry J. Fry

Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.

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For correspondence: fryt@mail.nih.gov

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TCR engagement negatively affects CD8 but not CD4 CAR T cell expansion and leukemic clearance

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