Research ArticleCancer

TCR engagement negatively affects CD8 but not CD4 CAR T cell expansion and leukemic clearance

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Science Translational Medicine  22 Nov 2017:
Vol. 9, Issue 417, eaag1209
DOI: 10.1126/scitranslmed.aag1209

Article Information

vol. 9 no. 417

PubMed: 
Print ISSN: 
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History: 
  • Received for publication May 20, 2016
  • Resubmitted June 6, 2017
  • Accepted for publication October 29, 2017
  • .

Author Information

  1. Yinmeng Yang1,2,
  2. M. Eric Kohler1,3,
  3. Christopher D. Chien1,
  4. Christopher T. Sauter1,
  5. Elad Jacoby1,
  6. Chunhua Yan4,
  7. Ying Hu4,
  8. Kelsey Wanhainen1,
  9. Haiying Qin1 and
  10. Terry J. Fry1,*
  1. 1Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
  2. 2Lombardi Comprehensive Cancer Center, Department of Oncology, Georgetown University, Washington, DC 20057, USA.
  3. 3Departments of Pediatric Oncology and Pediatric Hematology, Johns Hopkins University, Baltimore, MD 21287, USA.
  4. 4Center for Biomedical Informatics and Information Technology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
  1. *Corresponding author. Email: fryt{at}mail.nih.gov

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