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Research ResourcesCancer
A method of high-throughput functional evaluation of EGFR gene variants of unknown significance in cancer
- View ORCID ProfileShinji Kohsaka1,*,†,
- Masaaki Nagano2,3,†,
- View ORCID ProfileToshihide Ueno2,
- Yoshiyuki Suehara4,
- Takuo Hayashi5,
- Naoko Shimada6,
- Kazuhisa Takahashi6,
- Kenji Suzuki7,
- Kazuya Takamochi7,
- Fumiyuki Takahashi6 and
- View ORCID ProfileHiroyuki Mano2,8,*
- 1Department of Medical Genomics, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.
- 2Department of Cellular Signaling, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.
- 3Department of Thoracic Surgery, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.
- 4Department of Orthopedic Surgery, Graduate School of Medicine, Juntendo University, Bunkyo-ku, Tokyo 113-8431, Japan.
- 5Department of Human Pathology, Graduate School of Medicine, Juntendo University, Bunkyo-ku, Tokyo 113-8431, Japan.
- 6Department of Respiratory Medicine, Graduate School of Medicine, Juntendo University, Bunkyo-ku, Tokyo 113-8431, Japan.
- 7Department of General Thoracic Surgery, Graduate School of Medicine, Juntendo University, Bunkyo-ku, Tokyo 113-8431, Japan.
- 8National Cancer Center Research Institute, Chuo-ku, Tokyo 104-0045, Japan.
- ↵*Corresponding author. Email: kohsakas{at}m.u-tokyo.ac.jp (S.K.); hmano{at}m.u-tokyo.ac.jp (H.M.)
↵† These authors contributed equally to this work.
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Science Translational Medicine 15 Nov 2017:
Vol. 9, Issue 416, eaan6566
DOI: 10.1126/scitranslmed.aan6566
Vol. 9, Issue 416, eaan6566
DOI: 10.1126/scitranslmed.aan6566
Shinji Kohsaka
1Department of Medical Genomics, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.
Masaaki Nagano
2Department of Cellular Signaling, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.
3Department of Thoracic Surgery, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.
Toshihide Ueno
2Department of Cellular Signaling, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.
Yoshiyuki Suehara
4Department of Orthopedic Surgery, Graduate School of Medicine, Juntendo University, Bunkyo-ku, Tokyo 113-8431, Japan.
Takuo Hayashi
5Department of Human Pathology, Graduate School of Medicine, Juntendo University, Bunkyo-ku, Tokyo 113-8431, Japan.
Naoko Shimada
6Department of Respiratory Medicine, Graduate School of Medicine, Juntendo University, Bunkyo-ku, Tokyo 113-8431, Japan.
Kazuhisa Takahashi
6Department of Respiratory Medicine, Graduate School of Medicine, Juntendo University, Bunkyo-ku, Tokyo 113-8431, Japan.
Kenji Suzuki
7Department of General Thoracic Surgery, Graduate School of Medicine, Juntendo University, Bunkyo-ku, Tokyo 113-8431, Japan.
Kazuya Takamochi
7Department of General Thoracic Surgery, Graduate School of Medicine, Juntendo University, Bunkyo-ku, Tokyo 113-8431, Japan.
Fumiyuki Takahashi
6Department of Respiratory Medicine, Graduate School of Medicine, Juntendo University, Bunkyo-ku, Tokyo 113-8431, Japan.
Hiroyuki Mano
2Department of Cellular Signaling, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.
8National Cancer Center Research Institute, Chuo-ku, Tokyo 104-0045, Japan.
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