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A method of high-throughput functional evaluation of EGFR gene variants of unknown significance in cancer

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Science Translational Medicine  15 Nov 2017:
Vol. 9, Issue 416, eaan6566
DOI: 10.1126/scitranslmed.aan6566

Article Information

vol. 9 no. 416

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History: 
  • Received for publication May 17, 2017
  • Accepted for publication October 15, 2017
  • .

Author Information

  1. Shinji Kohsaka1,*,,
  2. Masaaki Nagano2,3,,
  3. Toshihide Ueno2,
  4. Yoshiyuki Suehara4,
  5. Takuo Hayashi5,
  6. Naoko Shimada6,
  7. Kazuhisa Takahashi6,
  8. Kenji Suzuki7,
  9. Kazuya Takamochi7,
  10. Fumiyuki Takahashi6 and
  11. Hiroyuki Mano2,8,*
  1. 1Department of Medical Genomics, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.
  2. 2Department of Cellular Signaling, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.
  3. 3Department of Thoracic Surgery, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.
  4. 4Department of Orthopedic Surgery, Graduate School of Medicine, Juntendo University, Bunkyo-ku, Tokyo 113-8431, Japan.
  5. 5Department of Human Pathology, Graduate School of Medicine, Juntendo University, Bunkyo-ku, Tokyo 113-8431, Japan.
  6. 6Department of Respiratory Medicine, Graduate School of Medicine, Juntendo University, Bunkyo-ku, Tokyo 113-8431, Japan.
  7. 7Department of General Thoracic Surgery, Graduate School of Medicine, Juntendo University, Bunkyo-ku, Tokyo 113-8431, Japan.
  8. 8National Cancer Center Research Institute, Chuo-ku, Tokyo 104-0045, Japan.
  1. *Corresponding author. Email: kohsakas{at}m.u-tokyo.ac.jp (S.K.); hmano{at}m.u-tokyo.ac.jp (H.M.)
    • These authors contributed equally to this work.

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