Research ArticleTransplantation
Apoptosis in mesenchymal stromal cells induces in vivo recipient-mediated immunomodulation
- Antonio Galleu1,
- Yanira Riffo-Vasquez2,
- Cristina Trento1,
- Cara Lomas3,4,
- Luigi Dolcetti1,
- Tik Shing Cheung1,
- Malte von Bonin5,
- Laura Barbieri1,
- Krishma Halai1,
- Sophie Ward3,4,
- Ling Weng1,
- Ronjon Chakraverty3,4,
- Giovanna Lombardi6,
- Fiona M. Watt7,
- Kim Orchard8,
- David I. Marks9,
- Jane Apperley10,
- Martin Bornhauser1,5,
- Henning Walczak4,*,
- Clare Bennett3,4,* and
- Francesco Dazzi1,10,†
- 1Regenerative Medicine, Division of Cancer Studies and Cancer Research UK King’s Health Partners, King’s College London, London SE5 9NU, UK.
- 2Institute of Pharmaceutical Science, King’s College London, London SE1 9NH, UK.
- 3Institute of Immunity and Transplantation, University College London, London NW3 2QG, UK.
- 4Cancer Institute, University College London, London WC1E 6DD, UK.
- 5University Hospital Carl Gustav Carus, 01307 Dresden, Germany.
- 6Medical Research Council Centre for Transplantation, King’s College London, London SE1 9RT, UK.
- 7Centre for Stem Cells and Regenerative Medicine, King’s College London, London SE1 9RT, UK.
- 8University Hospital Southampton NHS Foundation Trust, Southampton SO16 6YD, UK.
- 9Bristol Haematology and Oncology Centre, Bristol BS2 8ED, UK.
- 10Centre for Haematology, Imperial College London, London W12 0NN, UK.
- ↵†Corresponding author. Email: francesco.dazzi{at}kcl.ac.uk
↵* These authors contributed equally to this work.
See allHide authors and affiliations
Science Translational Medicine 15 Nov 2017:
Vol. 9, Issue 416, eaam7828
DOI: 10.1126/scitranslmed.aam7828
Vol. 9, Issue 416, eaam7828
DOI: 10.1126/scitranslmed.aam7828
Antonio Galleu
Regenerative Medicine, Division of Cancer Studies and Cancer Research UK King’s Health Partners, King’s College London, London SE5 9NU, UK.
Yanira Riffo-Vasquez
Institute of Pharmaceutical Science, King’s College London, London SE1 9NH, UK.
Cristina Trento
Regenerative Medicine, Division of Cancer Studies and Cancer Research UK King’s Health Partners, King’s College London, London SE5 9NU, UK.
Cara Lomas
Institute of Immunity and Transplantation, University College London, London NW3 2QG, UK.Cancer Institute, University College London, London WC1E 6DD, UK.
Luigi Dolcetti
Regenerative Medicine, Division of Cancer Studies and Cancer Research UK King’s Health Partners, King’s College London, London SE5 9NU, UK.
Tik Shing Cheung
Regenerative Medicine, Division of Cancer Studies and Cancer Research UK King’s Health Partners, King’s College London, London SE5 9NU, UK.
Malte von Bonin
University Hospital Carl Gustav Carus, 01307 Dresden, Germany.
Laura Barbieri
Regenerative Medicine, Division of Cancer Studies and Cancer Research UK King’s Health Partners, King’s College London, London SE5 9NU, UK.
Krishma Halai
Regenerative Medicine, Division of Cancer Studies and Cancer Research UK King’s Health Partners, King’s College London, London SE5 9NU, UK.
Sophie Ward
Institute of Immunity and Transplantation, University College London, London NW3 2QG, UK.Cancer Institute, University College London, London WC1E 6DD, UK.
Ling Weng
Regenerative Medicine, Division of Cancer Studies and Cancer Research UK King’s Health Partners, King’s College London, London SE5 9NU, UK.
Ronjon Chakraverty
Institute of Immunity and Transplantation, University College London, London NW3 2QG, UK.Cancer Institute, University College London, London WC1E 6DD, UK.
Giovanna Lombardi
Medical Research Council Centre for Transplantation, King’s College London, London SE1 9RT, UK.
Fiona M. Watt
Centre for Stem Cells and Regenerative Medicine, King’s College London, London SE1 9RT, UK.
Kim Orchard
University Hospital Southampton NHS Foundation Trust, Southampton SO16 6YD, UK.
David I. Marks
Bristol Haematology and Oncology Centre, Bristol BS2 8ED, UK.
Jane Apperley
Centre for Haematology, Imperial College London, London W12 0NN, UK.
Martin Bornhauser
Regenerative Medicine, Division of Cancer Studies and Cancer Research UK King’s Health Partners, King’s College London, London SE5 9NU, UK.University Hospital Carl Gustav Carus, 01307 Dresden, Germany.
Henning Walczak
Cancer Institute, University College London, London WC1E 6DD, UK.
Clare Bennett
Institute of Immunity and Transplantation, University College London, London NW3 2QG, UK.Cancer Institute, University College London, London WC1E 6DD, UK.
Francesco Dazzi
Regenerative Medicine, Division of Cancer Studies and Cancer Research UK King’s Health Partners, King’s College London, London SE5 9NU, UK.Centre for Haematology, Imperial College London, London W12 0NN, UK.
