Research ArticleTransplantation
Apoptosis in mesenchymal stromal cells induces in vivo recipient-mediated immunomodulation
- View ORCID ProfileAntonio Galleu1,
- View ORCID ProfileYanira Riffo-Vasquez2,
- Cristina Trento1,
- View ORCID ProfileCara Lomas3,4,
- View ORCID ProfileLuigi Dolcetti1,
- View ORCID ProfileTik Shing Cheung1,
- Malte von Bonin5,
- View ORCID ProfileLaura Barbieri1,
- Krishma Halai1,
- View ORCID ProfileSophie Ward3,4,
- Ling Weng1,
- Ronjon Chakraverty3,4,
- View ORCID ProfileGiovanna Lombardi6,
- View ORCID ProfileFiona M. Watt7,
- View ORCID ProfileKim Orchard8,
- David I. Marks9,
- Jane Apperley10,
- Martin Bornhauser1,5,
- View ORCID ProfileHenning Walczak4,*,
- View ORCID ProfileClare Bennett3,4,* and
- View ORCID ProfileFrancesco Dazzi1,10,†
- 1Regenerative Medicine, Division of Cancer Studies and Cancer Research UK King’s Health Partners, King’s College London, London SE5 9NU, UK.
- 2Institute of Pharmaceutical Science, King’s College London, London SE1 9NH, UK.
- 3Institute of Immunity and Transplantation, University College London, London NW3 2QG, UK.
- 4Cancer Institute, University College London, London WC1E 6DD, UK.
- 5University Hospital Carl Gustav Carus, 01307 Dresden, Germany.
- 6Medical Research Council Centre for Transplantation, King’s College London, London SE1 9RT, UK.
- 7Centre for Stem Cells and Regenerative Medicine, King’s College London, London SE1 9RT, UK.
- 8University Hospital Southampton NHS Foundation Trust, Southampton SO16 6YD, UK.
- 9Bristol Haematology and Oncology Centre, Bristol BS2 8ED, UK.
- 10Centre for Haematology, Imperial College London, London W12 0NN, UK.
- ↵†Corresponding author. Email: francesco.dazzi{at}kcl.ac.uk
↵* These authors contributed equally to this work.
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Science Translational Medicine 15 Nov 2017:
Vol. 9, Issue 416, eaam7828
DOI: 10.1126/scitranslmed.aam7828
Vol. 9, Issue 416, eaam7828
DOI: 10.1126/scitranslmed.aam7828
Antonio Galleu
1Regenerative Medicine, Division of Cancer Studies and Cancer Research UK King’s Health Partners, King’s College London, London SE5 9NU, UK.
Yanira Riffo-Vasquez
2Institute of Pharmaceutical Science, King’s College London, London SE1 9NH, UK.
Cristina Trento
1Regenerative Medicine, Division of Cancer Studies and Cancer Research UK King’s Health Partners, King’s College London, London SE5 9NU, UK.
Cara Lomas
3Institute of Immunity and Transplantation, University College London, London NW3 2QG, UK.
4Cancer Institute, University College London, London WC1E 6DD, UK.
Luigi Dolcetti
1Regenerative Medicine, Division of Cancer Studies and Cancer Research UK King’s Health Partners, King’s College London, London SE5 9NU, UK.
Tik Shing Cheung
1Regenerative Medicine, Division of Cancer Studies and Cancer Research UK King’s Health Partners, King’s College London, London SE5 9NU, UK.
Malte von Bonin
5University Hospital Carl Gustav Carus, 01307 Dresden, Germany.
Laura Barbieri
1Regenerative Medicine, Division of Cancer Studies and Cancer Research UK King’s Health Partners, King’s College London, London SE5 9NU, UK.
Krishma Halai
1Regenerative Medicine, Division of Cancer Studies and Cancer Research UK King’s Health Partners, King’s College London, London SE5 9NU, UK.
Sophie Ward
3Institute of Immunity and Transplantation, University College London, London NW3 2QG, UK.
4Cancer Institute, University College London, London WC1E 6DD, UK.
Ling Weng
1Regenerative Medicine, Division of Cancer Studies and Cancer Research UK King’s Health Partners, King’s College London, London SE5 9NU, UK.
Ronjon Chakraverty
3Institute of Immunity and Transplantation, University College London, London NW3 2QG, UK.
4Cancer Institute, University College London, London WC1E 6DD, UK.
Giovanna Lombardi
6Medical Research Council Centre for Transplantation, King’s College London, London SE1 9RT, UK.
Fiona M. Watt
7Centre for Stem Cells and Regenerative Medicine, King’s College London, London SE1 9RT, UK.
Kim Orchard
8University Hospital Southampton NHS Foundation Trust, Southampton SO16 6YD, UK.
David I. Marks
9Bristol Haematology and Oncology Centre, Bristol BS2 8ED, UK.
Jane Apperley
10Centre for Haematology, Imperial College London, London W12 0NN, UK.
Martin Bornhauser
1Regenerative Medicine, Division of Cancer Studies and Cancer Research UK King’s Health Partners, King’s College London, London SE5 9NU, UK.
5University Hospital Carl Gustav Carus, 01307 Dresden, Germany.
Henning Walczak
4Cancer Institute, University College London, London WC1E 6DD, UK.
Clare Bennett
3Institute of Immunity and Transplantation, University College London, London NW3 2QG, UK.
4Cancer Institute, University College London, London WC1E 6DD, UK.
Francesco Dazzi
1Regenerative Medicine, Division of Cancer Studies and Cancer Research UK King’s Health Partners, King’s College London, London SE5 9NU, UK.
10Centre for Haematology, Imperial College London, London W12 0NN, UK.
