Research ArticleAutoimmunity

PD-L1 genetic overexpression or pharmacological restoration in hematopoietic stem and progenitor cells reverses autoimmune diabetes

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Science Translational Medicine  15 Nov 2017:
Vol. 9, Issue 416, eaam7543
DOI: 10.1126/scitranslmed.aam7543

Article Information

vol. 9 no. 416

PubMed: 
Print ISSN: 
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History: 
  • Received for publication February 3, 2017
  • Resubmitted June 1, 2017
  • Accepted for publication August 14, 2017
  • .

Author Information

  1. Moufida Ben Nasr1,2,
  2. Sara Tezza1,
  3. Francesca D’Addio1,2,
  4. Chiara Mameli3,
  5. Vera Usuelli1,2,
  6. Anna Maestroni2,
  7. Domenico Corradi4,
  8. Silvana Belletti4,
  9. Luca Albarello5,
  10. Gabriella Becchi4,
  11. Gian Paolo Fadini6,
  12. Christian Schuetz7,
  13. James Markmann7,
  14. Clive Wasserfall8,
  15. Leonard Zon9,
  16. Gian Vincenzo Zuccotti2,3 and
  17. Paolo Fiorina1,2,10,*
  1. 1Nephrology Division, Boston Children’s Hospital, Harvard Medical School, Boston, MA 02115, USA.
  2. 2International Center for T1D, Pediatric Clinical Research Center Romeo ed Enrica Invernizzi, “L. Sacco” Department of Biomedical and Clinical Sciences, University of Milan, Milan 20157, Italy.
  3. 3Department of Pediatrics, Buzzi Children’s Hospital, Milan 20154, Italy.
  4. 4Pathology Unit, University of Parma, Parma 43126, Italy.
  5. 5Pathology Unit, Ospedale San Raffaele, Milan 20132, Italy.
  6. 6Department of Medicine, University of Padua, Padua 35100, Italy.
  7. 7Department of Surgery, Massachusetts General Hospital, Boston, MA 02114, USA.
  8. 8Department of Pathology, University of Florida, Gainesville, FL 32611, USA.
  9. 9Division of Hematology/Oncology, Boston Children’s Hospital, Harvard Medical School, Boston, MA 02115, USA.
  10. 10Department of Endocrinology, ASST Fatebenefratelli-Sacco, Milan 20121, Italy.
  1. *Corresponding author. Email: paolo.fiorina{at}childrens.harvard.edu

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