Research ArticleGUT MICROBIOTA
A role for bacterial urease in gut dysbiosis and Crohn’s disease
- Josephine Ni1,
- Ting-Chin David Shen1,
- Eric Z. Chen2,
- Kyle Bittinger3,
- Aubrey Bailey4,
- Manuela Roggiani5,
- Alexandra Sirota-Madi6,
- Elliot S. Friedman1,
- Lillian Chau1,
- Andrew Lin1,
- Ilana Nissim7,
- Justin Scott6,
- Abigail Lauder4,
- Christian Hoffmann4,
- Gloriany Rivas8,
- Lindsey Albenberg9,
- Robert N. Baldassano9,
- Jonathan Braun10,
- Ramnik J. Xavier6,10,11,
- Clary B. Clish6,
- Marc Yudkoff7,
- Hongzhe Li2,
- Mark Goulian5,
- Frederic D. Bushman4,
- James D. Lewis1,2 and
- Gary D. Wu1,*
- 1Division of Gastroenterology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
- 2Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
- 3Division of Gastroenterology, Hepatology, and Nutrition, The Children’s Hospital of Philadelphia, Philadelphia, PA 19104, USA.
- 4Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
- 5Department of Biology, University of Pennsylvania, Philadelphia, PA 19104, USA.
- 6Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard University, Cambridge, MA 02142, USA.
- 7Division of Child Development, Rehabilitation, and Metabolic Disease, The Children’s Hospital of Philadelphia, Philadelphia, PA 19104, USA.
- 8Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
- 9Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA.
- 10Center for the Study of Inflammatory Bowel Disease, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
- 11Center for Microbiome Informatics and Therapeutics, MIT, Cambridge, MA 02139, USA.
- ↵*Corresponding author. Email: gdwu{at}pennmedicine.upenn.edu
See allHide authors and affiliations
Science Translational Medicine 15 Nov 2017:
Vol. 9, Issue 416, eaah6888
DOI: 10.1126/scitranslmed.aah6888
Vol. 9, Issue 416, eaah6888
DOI: 10.1126/scitranslmed.aah6888
Josephine Ni
Division of Gastroenterology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Ting-Chin David Shen
Division of Gastroenterology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Eric Z. Chen
Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Kyle Bittinger
Division of Gastroenterology, Hepatology, and Nutrition, The Children’s Hospital of Philadelphia, Philadelphia, PA 19104, USA.
Aubrey Bailey
Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Manuela Roggiani
Department of Biology, University of Pennsylvania, Philadelphia, PA 19104, USA.
Alexandra Sirota-Madi
Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard University, Cambridge, MA 02142, USA.
Elliot S. Friedman
Division of Gastroenterology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Lillian Chau
Division of Gastroenterology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Andrew Lin
Division of Gastroenterology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Ilana Nissim
Division of Child Development, Rehabilitation, and Metabolic Disease, The Children’s Hospital of Philadelphia, Philadelphia, PA 19104, USA.
Justin Scott
Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard University, Cambridge, MA 02142, USA.
Abigail Lauder
Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Christian Hoffmann
Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Gloriany Rivas
Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Lindsey Albenberg
Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA.
Robert N. Baldassano
Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA.
Jonathan Braun
Center for the Study of Inflammatory Bowel Disease, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
Ramnik J. Xavier
Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard University, Cambridge, MA 02142, USA.Center for the Study of Inflammatory Bowel Disease, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.Center for Microbiome Informatics and Therapeutics, MIT, Cambridge, MA 02139, USA.
Clary B. Clish
Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard University, Cambridge, MA 02142, USA.
Marc Yudkoff
Division of Child Development, Rehabilitation, and Metabolic Disease, The Children’s Hospital of Philadelphia, Philadelphia, PA 19104, USA.
Hongzhe Li
Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Mark Goulian
Department of Biology, University of Pennsylvania, Philadelphia, PA 19104, USA.
Frederic D. Bushman
Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
James D. Lewis
Division of Gastroenterology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Gary D. Wu
Division of Gastroenterology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
