Research ArticleGUT MICROBIOTA
A role for bacterial urease in gut dysbiosis and Crohn’s disease
- View ORCID ProfileJosephine Ni1,
- Ting-Chin David Shen1,
- Eric Z. Chen2,
- Kyle Bittinger3,
- View ORCID ProfileAubrey Bailey4,
- Manuela Roggiani5,
- View ORCID ProfileAlexandra Sirota-Madi6,
- View ORCID ProfileElliot S. Friedman1,
- Lillian Chau1,
- View ORCID ProfileAndrew Lin1,
- Ilana Nissim7,
- View ORCID ProfileJustin Scott6,
- View ORCID ProfileAbigail Lauder4,
- View ORCID ProfileChristian Hoffmann4,
- View ORCID ProfileGloriany Rivas8,
- View ORCID ProfileLindsey Albenberg9,
- View ORCID ProfileRobert N. Baldassano9,
- View ORCID ProfileJonathan Braun10,
- View ORCID ProfileRamnik J. Xavier6,10,11,
- View ORCID ProfileClary B. Clish6,
- View ORCID ProfileMarc Yudkoff7,
- View ORCID ProfileHongzhe Li2,
- View ORCID ProfileMark Goulian5,
- Frederic D. Bushman4,
- View ORCID ProfileJames D. Lewis1,2 and
- View ORCID ProfileGary D. Wu1,*
- 1Division of Gastroenterology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
- 2Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
- 3Division of Gastroenterology, Hepatology, and Nutrition, The Children’s Hospital of Philadelphia, Philadelphia, PA 19104, USA.
- 4Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
- 5Department of Biology, University of Pennsylvania, Philadelphia, PA 19104, USA.
- 6Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard University, Cambridge, MA 02142, USA.
- 7Division of Child Development, Rehabilitation, and Metabolic Disease, The Children’s Hospital of Philadelphia, Philadelphia, PA 19104, USA.
- 8Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
- 9Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA.
- 10Center for the Study of Inflammatory Bowel Disease, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
- 11Center for Microbiome Informatics and Therapeutics, MIT, Cambridge, MA 02139, USA.
- ↵*Corresponding author. Email: gdwu{at}pennmedicine.upenn.edu
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Science Translational Medicine 15 Nov 2017:
Vol. 9, Issue 416, eaah6888
DOI: 10.1126/scitranslmed.aah6888
Vol. 9, Issue 416, eaah6888
DOI: 10.1126/scitranslmed.aah6888
Josephine Ni
1Division of Gastroenterology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Ting-Chin David Shen
1Division of Gastroenterology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Eric Z. Chen
2Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Kyle Bittinger
3Division of Gastroenterology, Hepatology, and Nutrition, The Children’s Hospital of Philadelphia, Philadelphia, PA 19104, USA.
Aubrey Bailey
4Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Manuela Roggiani
5Department of Biology, University of Pennsylvania, Philadelphia, PA 19104, USA.
Alexandra Sirota-Madi
6Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard University, Cambridge, MA 02142, USA.
Elliot S. Friedman
1Division of Gastroenterology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Lillian Chau
1Division of Gastroenterology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Andrew Lin
1Division of Gastroenterology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Ilana Nissim
7Division of Child Development, Rehabilitation, and Metabolic Disease, The Children’s Hospital of Philadelphia, Philadelphia, PA 19104, USA.
Justin Scott
6Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard University, Cambridge, MA 02142, USA.
Abigail Lauder
4Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Christian Hoffmann
4Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Gloriany Rivas
8Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Lindsey Albenberg
9Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA.
Robert N. Baldassano
9Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA.
Jonathan Braun
10Center for the Study of Inflammatory Bowel Disease, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
Ramnik J. Xavier
6Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard University, Cambridge, MA 02142, USA.
10Center for the Study of Inflammatory Bowel Disease, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
11Center for Microbiome Informatics and Therapeutics, MIT, Cambridge, MA 02139, USA.
Clary B. Clish
6Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard University, Cambridge, MA 02142, USA.
Marc Yudkoff
7Division of Child Development, Rehabilitation, and Metabolic Disease, The Children’s Hospital of Philadelphia, Philadelphia, PA 19104, USA.
Hongzhe Li
2Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Mark Goulian
5Department of Biology, University of Pennsylvania, Philadelphia, PA 19104, USA.
Frederic D. Bushman
4Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
James D. Lewis
1Division of Gastroenterology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
2Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Gary D. Wu
1Division of Gastroenterology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
