Research ArticleGUT MICROBIOTA

A role for bacterial urease in gut dysbiosis and Crohn’s disease

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Science Translational Medicine  15 Nov 2017:
Vol. 9, Issue 416, eaah6888
DOI: 10.1126/scitranslmed.aah6888

Article Information

vol. 9 no. 416

PubMed: 
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History: 
  • Received for publication August 7, 2016
  • Resubmitted April 5, 2017
  • Accepted for publication May 26, 2017
  • .

Author Information

  1. Josephine Ni1,
  2. Ting-Chin David Shen1,
  3. Eric Z. Chen2,
  4. Kyle Bittinger3,
  5. Aubrey Bailey4,
  6. Manuela Roggiani5,
  7. Alexandra Sirota-Madi6,
  8. Elliot S. Friedman1,
  9. Lillian Chau1,
  10. Andrew Lin1,
  11. Ilana Nissim7,
  12. Justin Scott6,
  13. Abigail Lauder4,
  14. Christian Hoffmann4,
  15. Gloriany Rivas8,
  16. Lindsey Albenberg9,
  17. Robert N. Baldassano9,
  18. Jonathan Braun10,
  19. Ramnik J. Xavier6,10,11,
  20. Clary B. Clish6,
  21. Marc Yudkoff7,
  22. Hongzhe Li2,
  23. Mark Goulian5,
  24. Frederic D. Bushman4,
  25. James D. Lewis1,2 and
  26. Gary D. Wu1,*
  1. 1Division of Gastroenterology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
  2. 2Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
  3. 3Division of Gastroenterology, Hepatology, and Nutrition, The Children’s Hospital of Philadelphia, Philadelphia, PA 19104, USA.
  4. 4Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
  5. 5Department of Biology, University of Pennsylvania, Philadelphia, PA 19104, USA.
  6. 6Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard University, Cambridge, MA 02142, USA.
  7. 7Division of Child Development, Rehabilitation, and Metabolic Disease, The Children’s Hospital of Philadelphia, Philadelphia, PA 19104, USA.
  8. 8Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
  9. 9Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA.
  10. 10Center for the Study of Inflammatory Bowel Disease, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
  11. 11Center for Microbiome Informatics and Therapeutics, MIT, Cambridge, MA 02139, USA.
  1. *Corresponding author. Email: gdwu{at}pennmedicine.upenn.edu

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