Contents
15 November 2017
Vol 9, Issue 416
Vol 9, Issue 416
Research Articles
- Lung cancer–associated pulmonary hypertension: Role of microenvironmental inflammation based on tumor cell–immune cell cross-talk
Lung cancer–associated pulmonary hypertension is associated with microenvironmental inflammation caused by tumor cell–immune cell cross-talk.
- PD-L1 genetic overexpression or pharmacological restoration in hematopoietic stem and progenitor cells reverses autoimmune diabetes
Restoration of a PD-L1 defect in HSPCs reverses diabetes in NOD mice and thus may represent a potential cure for T1D.
- Apoptosis in mesenchymal stromal cells induces in vivo recipient-mediated immunomodulation
Mesenchymal stromal cell apoptosis, induced in vivo by recipient cytotoxic cells, is required for immunosuppression and clinical responses.
- A role for bacterial urease in gut dysbiosis and Crohn’s disease
Bacterial urease activity of the gut microbiota alters nitrogen flux, leading to gut dysbiosis and worsening of colitis in mice.
Research Resource
- A method of high-throughput functional evaluation of EGFR gene variants of unknown significance in cancer
A method for high-throughput functional analysis identifies drug-insensitive EGFR mutations in tumors.
Editors' Choice
- A 3D view of tumor heterogeneity
Solid tumor clearing and light-sheet microscopy improves interrogation of intratumoral heterogeneity.
- An antioxidant to attenuate aortic aging
Supplementation with the mitochondrial targeted antioxidant MitoQ for 4 weeks decreased aortic stiffness in old mice.
- Vascular endothelial cells take hematopoietic stem cells to school
The bone marrow vascular endothelial cell niche plays a critical role in regulating hematopoietic system aging by influencing the phenotype of hematopoietic stem cells.
- Epilepsy clocks in
Circadian CLOCK gene expression is reduced in human epileptic brain tissue, and its deletion is epileptogenic in mice.
About The Cover
ONLINE COVER Lung Cancer Drives Pulmonary Hypertension. This image shows a ring of lung cancer cells and interspersed immune cells surrounding a blood vessel. Pullamsetti et al. discovered that lung cancer can induce pulmonary hypertension through inflammation-enhancing cross-talk between the cancer cells and immune cells in the tumor microenvironment, which may explain some of the clinical symptoms seen in lung cancer patients, such as shortness of breath. [CREDIT: RAJKUMAR SAVAI/MAX PLANCK INSTITUTE FOR HEART AND LUNG RESEARCH]