Research ArticleCancer

Matrix-binding checkpoint immunotherapies enhance antitumor efficacy and reduce adverse events

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Science Translational Medicine  08 Nov 2017:
Vol. 9, Issue 415, eaan0401
DOI: 10.1126/scitranslmed.aan0401

Keeping immunotherapy closer to home

Immune checkpoint inhibitors are gaining increasing prominence in the field of cancer because of their remarkable success record in many difficult-to-treat tumor types. Unfortunately, activation of the immune system against tumors does not occur in isolation, and these drugs are also associated with a host of immune side effects, which limit their usefulness. To decrease systemic toxicity, Ishihara et al. conjugated immune checkpoint antibodies to a matrix-binding peptide and showed that peritumoral injection of these conjugated antibodies results in their retention in tumor tissue, effective antitumor response, and systemic antitumor immunity with fewer adverse effects.

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