Research ArticleHeart Failure
Accumulation of 5-oxoproline in myocardial dysfunction and the protective effects of OPLAH
- View ORCID ProfileAtze van der Pol1,
- Andres Gil2,
- View ORCID ProfileHerman H. W. Silljé1,
- Jasper Tromp1,3,
- Ekaterina S. Ovchinnikova1,4,
- Inge Vreeswijk-Baudoin1,
- Martijn Hoes1,
- Ibrahim J. Domian5,6,
- Bart van de Sluis7,
- View ORCID ProfileJan M. van Deursen8,
- Adriaan A. Voors1,
- Dirk J. van Veldhuisen1,
- View ORCID ProfileWiek H. van Gilst1,
- View ORCID ProfileEugene Berezikov4,
- View ORCID ProfilePim van der Harst1,
- View ORCID ProfileRudolf A. de Boer1,
- View ORCID ProfileRainer Bischoff2 and
- View ORCID ProfilePeter van der Meer1,*
- 1Department of Cardiology, University Medical Center Groningen, University of Groningen, 9713 AV Groningen, Netherlands.
- 2Department of Pharmacy, Analytical Biochemistry, University of Groningen, 9713 AV Groningen, Netherlands.
- 3National Heart Centre Singapore, 169609 Singapore, Singapore.
- 4European Research Institute for the Biology of Aging, Laboratory of Stem Cell Regulation and Mechanisms of Regeneration, University of Groningen, 9713 AV Groningen, Netherlands.
- 5Cardiovascular Research Center, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.
- 6Harvard Stem Cell Institute, Cambridge, MA 02138, USA.
- 7Molecular Genetics Section, Department of Pediatrics, University Medical Center Groningen, University of Groningen, 9713 AV Groningen, Netherlands.
- 8Department of Pediatrics, Mayo Clinic, Rochester, MN 55905, USA.
- ↵*Corresponding author. Email: p.van.der.meer{at}umcg.nl
See allHide authors and affiliations
Science Translational Medicine 08 Nov 2017:
Vol. 9, Issue 415, eaam8574
DOI: 10.1126/scitranslmed.aam8574
Vol. 9, Issue 415, eaam8574
DOI: 10.1126/scitranslmed.aam8574
Atze van der Pol
1Department of Cardiology, University Medical Center Groningen, University of Groningen, 9713 AV Groningen, Netherlands.
Andres Gil
2Department of Pharmacy, Analytical Biochemistry, University of Groningen, 9713 AV Groningen, Netherlands.
Herman H. W. Silljé
1Department of Cardiology, University Medical Center Groningen, University of Groningen, 9713 AV Groningen, Netherlands.
Jasper Tromp
1Department of Cardiology, University Medical Center Groningen, University of Groningen, 9713 AV Groningen, Netherlands.
3National Heart Centre Singapore, 169609 Singapore, Singapore.
Ekaterina S. Ovchinnikova
1Department of Cardiology, University Medical Center Groningen, University of Groningen, 9713 AV Groningen, Netherlands.
4European Research Institute for the Biology of Aging, Laboratory of Stem Cell Regulation and Mechanisms of Regeneration, University of Groningen, 9713 AV Groningen, Netherlands.
Inge Vreeswijk-Baudoin
1Department of Cardiology, University Medical Center Groningen, University of Groningen, 9713 AV Groningen, Netherlands.
Martijn Hoes
1Department of Cardiology, University Medical Center Groningen, University of Groningen, 9713 AV Groningen, Netherlands.
Ibrahim J. Domian
5Cardiovascular Research Center, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.
6Harvard Stem Cell Institute, Cambridge, MA 02138, USA.
Bart van de Sluis
7Molecular Genetics Section, Department of Pediatrics, University Medical Center Groningen, University of Groningen, 9713 AV Groningen, Netherlands.
Jan M. van Deursen
8Department of Pediatrics, Mayo Clinic, Rochester, MN 55905, USA.
Adriaan A. Voors
1Department of Cardiology, University Medical Center Groningen, University of Groningen, 9713 AV Groningen, Netherlands.
Dirk J. van Veldhuisen
1Department of Cardiology, University Medical Center Groningen, University of Groningen, 9713 AV Groningen, Netherlands.
Wiek H. van Gilst
1Department of Cardiology, University Medical Center Groningen, University of Groningen, 9713 AV Groningen, Netherlands.
Eugene Berezikov
4European Research Institute for the Biology of Aging, Laboratory of Stem Cell Regulation and Mechanisms of Regeneration, University of Groningen, 9713 AV Groningen, Netherlands.
Pim van der Harst
1Department of Cardiology, University Medical Center Groningen, University of Groningen, 9713 AV Groningen, Netherlands.
Rudolf A. de Boer
1Department of Cardiology, University Medical Center Groningen, University of Groningen, 9713 AV Groningen, Netherlands.
Rainer Bischoff
2Department of Pharmacy, Analytical Biochemistry, University of Groningen, 9713 AV Groningen, Netherlands.
Peter van der Meer
1Department of Cardiology, University Medical Center Groningen, University of Groningen, 9713 AV Groningen, Netherlands.
