Research ArticleHeart Failure
Accumulation of 5-oxoproline in myocardial dysfunction and the protective effects of OPLAH
- Atze van der Pol1,
- Andres Gil2,
- Herman H. W. Silljé1,
- Jasper Tromp1,3,
- Ekaterina S. Ovchinnikova1,4,
- Inge Vreeswijk-Baudoin1,
- Martijn Hoes1,
- Ibrahim J. Domian5,6,
- Bart van de Sluis7,
- Jan M. van Deursen8,
- Adriaan A. Voors1,
- Dirk J. van Veldhuisen1,
- Wiek H. van Gilst1,
- Eugene Berezikov4,
- Pim van der Harst1,
- Rudolf A. de Boer1,
- Rainer Bischoff2 and
- Peter van der Meer1,*
- 1Department of Cardiology, University Medical Center Groningen, University of Groningen, 9713 AV Groningen, Netherlands.
- 2Department of Pharmacy, Analytical Biochemistry, University of Groningen, 9713 AV Groningen, Netherlands.
- 3National Heart Centre Singapore, 169609 Singapore, Singapore.
- 4European Research Institute for the Biology of Aging, Laboratory of Stem Cell Regulation and Mechanisms of Regeneration, University of Groningen, 9713 AV Groningen, Netherlands.
- 5Cardiovascular Research Center, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.
- 6Harvard Stem Cell Institute, Cambridge, MA 02138, USA.
- 7Molecular Genetics Section, Department of Pediatrics, University Medical Center Groningen, University of Groningen, 9713 AV Groningen, Netherlands.
- 8Department of Pediatrics, Mayo Clinic, Rochester, MN 55905, USA.
- ↵*Corresponding author. Email: p.van.der.meer{at}umcg.nl
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Science Translational Medicine 08 Nov 2017:
Vol. 9, Issue 415, eaam8574
DOI: 10.1126/scitranslmed.aam8574
Vol. 9, Issue 415, eaam8574
DOI: 10.1126/scitranslmed.aam8574
Atze van der Pol
Department of Cardiology, University Medical Center Groningen, University of Groningen, 9713 AV Groningen, Netherlands.
Andres Gil
Department of Pharmacy, Analytical Biochemistry, University of Groningen, 9713 AV Groningen, Netherlands.
Herman H. W. Silljé
Department of Cardiology, University Medical Center Groningen, University of Groningen, 9713 AV Groningen, Netherlands.
Jasper Tromp
Department of Cardiology, University Medical Center Groningen, University of Groningen, 9713 AV Groningen, Netherlands.National Heart Centre Singapore, 169609 Singapore, Singapore.
Ekaterina S. Ovchinnikova
Department of Cardiology, University Medical Center Groningen, University of Groningen, 9713 AV Groningen, Netherlands.European Research Institute for the Biology of Aging, Laboratory of Stem Cell Regulation and Mechanisms of Regeneration, University of Groningen, 9713 AV Groningen, Netherlands.
Inge Vreeswijk-Baudoin
Department of Cardiology, University Medical Center Groningen, University of Groningen, 9713 AV Groningen, Netherlands.
Martijn Hoes
Department of Cardiology, University Medical Center Groningen, University of Groningen, 9713 AV Groningen, Netherlands.
Ibrahim J. Domian
Cardiovascular Research Center, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.Harvard Stem Cell Institute, Cambridge, MA 02138, USA.
Bart van de Sluis
Molecular Genetics Section, Department of Pediatrics, University Medical Center Groningen, University of Groningen, 9713 AV Groningen, Netherlands.
Jan M. van Deursen
Department of Pediatrics, Mayo Clinic, Rochester, MN 55905, USA.
Adriaan A. Voors
Department of Cardiology, University Medical Center Groningen, University of Groningen, 9713 AV Groningen, Netherlands.
Dirk J. van Veldhuisen
Department of Cardiology, University Medical Center Groningen, University of Groningen, 9713 AV Groningen, Netherlands.
Wiek H. van Gilst
Department of Cardiology, University Medical Center Groningen, University of Groningen, 9713 AV Groningen, Netherlands.
Eugene Berezikov
European Research Institute for the Biology of Aging, Laboratory of Stem Cell Regulation and Mechanisms of Regeneration, University of Groningen, 9713 AV Groningen, Netherlands.
Pim van der Harst
Department of Cardiology, University Medical Center Groningen, University of Groningen, 9713 AV Groningen, Netherlands.
Rudolf A. de Boer
Department of Cardiology, University Medical Center Groningen, University of Groningen, 9713 AV Groningen, Netherlands.
Rainer Bischoff
Department of Pharmacy, Analytical Biochemistry, University of Groningen, 9713 AV Groningen, Netherlands.
Peter van der Meer
Department of Cardiology, University Medical Center Groningen, University of Groningen, 9713 AV Groningen, Netherlands.
