08 November 2017
Vol 9, Issue 415

About The Cover

Cover image expansion

ONLINE COVER Time to Heal. Fibroblasts help wounds heal by secreting and organizing matrix proteins. Here, we see fibroblasts migrating into a wound from surrounding skin tissue (cyan). The surface projections of the fibroblasts are shown in magenta; red shows staining for vimentin, a cytoskeletal filament. Hoyle et al. discovered that actin cytoskeletal dynamics are regulated by circadian rhythms during wound healing. Wounds acquired during the circadian active period showed more migratory cells and healed faster than did wounds obtained during the rest period. Strategies to reset the cellular clock could potentially improve wound healing efficiency. [CREDIT: N. P. HOYLE/MRC LABORATORY OF MOLECULAR BIOLOGY, UK]