Research ArticleStem Cells

A distinct hematopoietic stem cell population for rapid multilineage engraftment in nonhuman primates

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Science Translational Medicine  01 Nov 2017:
Vol. 9, Issue 414, eaan1145
DOI: 10.1126/scitranslmed.aan1145

Refining the gold standard

CD34-positive hematopoietic cells are the gold standard for stem cell therapy and transplantation of stem cell–enriched grafts. However, most of the cells within this population will not contribute to engraftment. Using a robust nonhuman primate transplantation model, Radtke et al. identified a stem cell–enriched subpopulation of CD34-positive cells that was exclusively responsible for multilineage engraftment. The cell dose of this subpopulation correlated with neutrophil and platelet recovery and reliably predicted overall transplant success. The authors observed phenotypic and transcriptomic similarities between these cells and human hematopoietic cells with high engraftment and repopulating potential. These data suggest a refined subpopulation of CD34-positive cells for use in transplantation and gene therapy/editing approaches.

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