01 November 2017
Vol 9, Issue 414

About The Cover

Cover image expansion

ONLINE COVER Building Blood Vessels. This image shows a cross-section of a tissue-engineered vascular graft. Syedain et al. constructed these tubes from fibrin protein and human skin cells. During culture in a bioreactor, skin cells converted the fibrin into collagen. After removing the cells from the tubes, these grafts were implanted into baboons as arteriovenous grafts. Over the course of 6 months, cells repopulated the grafts and the grafts maintained patency. These grafts offer a biological alternative to synthetic vascular grafts used for hemodialysis access in patients. [CREDIT: COLE FEAGLER/UNIVERSITY OF MINNESOTA]