Research ArticlePulmonary Arterial Hypertension
Inhibition of pyruvate dehydrogenase kinase improves pulmonary arterial hypertension in genetically susceptible patients
- View ORCID ProfileEvangelos D. Michelakis1,*,
- Vikram Gurtu1,
- Linda Webster1,
- Gareth Barnes2,
- View ORCID ProfileGeoffrey Watson2,
- View ORCID ProfileLuke Howard3,
- John Cupitt2,
- Ian Paterson1,
- Richard B. Thompson4,
- Kelvin Chow4,
- View ORCID ProfileDeclan P. O’Regan5,
- View ORCID ProfileLan Zhao2,
- View ORCID ProfileJohn Wharton2,
- View ORCID ProfileDavid G. Kiely6,
- Adam Kinnaird1,
- View ORCID ProfileAristeidis E. Boukouris1,
- View ORCID ProfileChris White7,
- View ORCID ProfileJayan Nagendran7,
- View ORCID ProfileDarren H. Freed7,
- Stephen J. Wort8,
- J. Simon R. Gibbs3 and
- View ORCID ProfileMartin R. Wilkins2,*
- 1Department of Medicine, University of Alberta, Edmonton, Alberta T6G2B7, Canada.
- 2Department of Medicine, Imperial College London, London W12 0NN, UK.
- 3National Pulmonary Hypertension Service, Imperial College Healthcare National Health Service Trust, Hammersmith Hospital, Du Cane Road, London W12 0NN, UK.
- 4Department of Biomedical Engineering, University of Alberta, Edmonton, Alberta T6G2B7, Canada.
- 5Medical Research Council, London Institute of Medical Sciences, Hammersmith Hospital Campus, Imperial College London, London W12 0NN, UK.
- 6Sheffield Pulmonary Vascular Disease Unit, Royal Hallamshire Hospital, Sheffield S10 2JF, UK.
- 7Department of Surgery, University of Alberta, Edmonton, Alberta T6G2B7, Canada.
- 8National Heart and Lung Institute, Imperial College London, Dovehouse Street, London SW3 6LY, UK.
- ↵*Corresponding author. Email: em2{at}ualberta.ca (E.D.M.); m.wilkins{at}imperial.ac.uk (M.R.W.)
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Science Translational Medicine 25 Oct 2017:
Vol. 9, Issue 413, eaao4583
DOI: 10.1126/scitranslmed.aao4583
Vol. 9, Issue 413, eaao4583
DOI: 10.1126/scitranslmed.aao4583
Evangelos D. Michelakis
1Department of Medicine, University of Alberta, Edmonton, Alberta T6G2B7, Canada.
Vikram Gurtu
1Department of Medicine, University of Alberta, Edmonton, Alberta T6G2B7, Canada.
Linda Webster
1Department of Medicine, University of Alberta, Edmonton, Alberta T6G2B7, Canada.
Gareth Barnes
2Department of Medicine, Imperial College London, London W12 0NN, UK.
Geoffrey Watson
2Department of Medicine, Imperial College London, London W12 0NN, UK.
Luke Howard
3National Pulmonary Hypertension Service, Imperial College Healthcare National Health Service Trust, Hammersmith Hospital, Du Cane Road, London W12 0NN, UK.
John Cupitt
2Department of Medicine, Imperial College London, London W12 0NN, UK.
Ian Paterson
1Department of Medicine, University of Alberta, Edmonton, Alberta T6G2B7, Canada.
Richard B. Thompson
4Department of Biomedical Engineering, University of Alberta, Edmonton, Alberta T6G2B7, Canada.
Kelvin Chow
4Department of Biomedical Engineering, University of Alberta, Edmonton, Alberta T6G2B7, Canada.
Declan P. O’Regan
5Medical Research Council, London Institute of Medical Sciences, Hammersmith Hospital Campus, Imperial College London, London W12 0NN, UK.
Lan Zhao
2Department of Medicine, Imperial College London, London W12 0NN, UK.
John Wharton
2Department of Medicine, Imperial College London, London W12 0NN, UK.
David G. Kiely
6Sheffield Pulmonary Vascular Disease Unit, Royal Hallamshire Hospital, Sheffield S10 2JF, UK.
Adam Kinnaird
1Department of Medicine, University of Alberta, Edmonton, Alberta T6G2B7, Canada.
Aristeidis E. Boukouris
1Department of Medicine, University of Alberta, Edmonton, Alberta T6G2B7, Canada.
Chris White
7Department of Surgery, University of Alberta, Edmonton, Alberta T6G2B7, Canada.
Jayan Nagendran
7Department of Surgery, University of Alberta, Edmonton, Alberta T6G2B7, Canada.
Darren H. Freed
7Department of Surgery, University of Alberta, Edmonton, Alberta T6G2B7, Canada.
Stephen J. Wort
8National Heart and Lung Institute, Imperial College London, Dovehouse Street, London SW3 6LY, UK.
J. Simon R. Gibbs
3National Pulmonary Hypertension Service, Imperial College Healthcare National Health Service Trust, Hammersmith Hospital, Du Cane Road, London W12 0NN, UK.
Martin R. Wilkins
2Department of Medicine, Imperial College London, London W12 0NN, UK.
