Research ArticlePulmonary Arterial Hypertension

Inhibition of pyruvate dehydrogenase kinase improves pulmonary arterial hypertension in genetically susceptible patients

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Science Translational Medicine  25 Oct 2017:
Vol. 9, Issue 413, eaao4583
DOI: 10.1126/scitranslmed.aao4583

Article Information

vol. 9 no. 413

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History: 
  • Received for publication July 27, 2017
  • Accepted for publication September 22, 2017
  • .

Author Information

  1. Evangelos D. Michelakis1,*,
  2. Vikram Gurtu1,
  3. Linda Webster1,
  4. Gareth Barnes2,
  5. Geoffrey Watson2,
  6. Luke Howard3,
  7. John Cupitt2,
  8. Ian Paterson1,
  9. Richard B. Thompson4,
  10. Kelvin Chow4,
  11. Declan P. O’Regan5,
  12. Lan Zhao2,
  13. John Wharton2,
  14. David G. Kiely6,
  15. Adam Kinnaird1,
  16. Aristeidis E. Boukouris1,
  17. Chris White7,
  18. Jayan Nagendran7,
  19. Darren H. Freed7,
  20. Stephen J. Wort8,
  21. J. Simon R. Gibbs3 and
  22. Martin R. Wilkins2,*
  1. 1Department of Medicine, University of Alberta, Edmonton, Alberta T6G2B7, Canada.
  2. 2Department of Medicine, Imperial College London, London W12 0NN, UK.
  3. 3National Pulmonary Hypertension Service, Imperial College Healthcare National Health Service Trust, Hammersmith Hospital, Du Cane Road, London W12 0NN, UK.
  4. 4Department of Biomedical Engineering, University of Alberta, Edmonton, Alberta T6G2B7, Canada.
  5. 5Medical Research Council, London Institute of Medical Sciences, Hammersmith Hospital Campus, Imperial College London, London W12 0NN, UK.
  6. 6Sheffield Pulmonary Vascular Disease Unit, Royal Hallamshire Hospital, Sheffield S10 2JF, UK.
  7. 7Department of Surgery, University of Alberta, Edmonton, Alberta T6G2B7, Canada.
  8. 8National Heart and Lung Institute, Imperial College London, Dovehouse Street, London SW3 6LY, UK.
  1. *Corresponding author. Email: em2{at}ualberta.ca (E.D.M.); m.wilkins{at}imperial.ac.uk (M.R.W.)

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