Contents
25 October 2017
Vol 9, Issue 413
Vol 9, Issue 413
Research Articles
- Inhibition of pyruvate dehydrogenase kinase improves pulmonary arterial hypertension in genetically susceptible patients
Metabolic modulation with dichloroacetate improves hemodynamics in genetically susceptible patients with idiopathic pulmonary arterial hypertension.
- Overcoming mutational complexity in acute myeloid leukemia by inhibition of critical pathways
Targeting leukemogenic mutations identified by functional single-cell genomics eliminated human AML in vivo.
- Evolution-informed forecasting of seasonal influenza A (H3N2)
A transmission model including virus evolution quantified from genetic sequences produces H3N2 influenza forecasts ahead of the season.
Reports
- Transplantation of wild-type mouse hematopoietic stem and progenitor cells ameliorates deficits in a mouse model of Friedreich’s ataxia
YG8R mice, a model of Friedreich’s ataxia, show amelioration of the disease phenotype when transplanted with wild-type mouse hematopoietic stem and progenitor cells.
- Longitudinal genomic surveillance of MRSA in the UK reveals transmission patterns in hospitals and the community
Longitudinal genomic and epidemiological surveillance of methicillin-resistant Staphylococcus aureus in the UK reveals extensive transmission in hospitals and the community.
Editors' Choice
- Through the smoke lies a further threat
CD4+ lymphocyte differentiation is enhanced in patients with concomitant COPD and lung cancer, improving responses to immune checkpoint inhibition.
- The new stars of synaptic regulation
Astrocytes regulate synaptic function in amygdala.
- Macrophage magic: Why more is better for skin wound healing
Scaffold-seeded macrophage transplantation to a skin wound site accelerates healing.
- Gammaherpesvirus is nothing to sneeze at
Gammaherpesvirus protects against allergic asthma by inducing the replacement of alveolar macrophages.
About The Cover
ONLINE COVER Clearing a Path for PAH Therapy. Occlusion of the lumen of pulmonary arteries, shown in the image here, occurs due to maladaptive vascular remodeling in pulmonary arterial hypertension. Michelakis et al. discovered that treatment with dichloroacetate, a small molecule used as a cancer therapy that inhibits a mitochondrial enzyme, reduced mean pulmonary artery pressure and improved 6-min walk tests in patients with idiopathic pulmonary arterial hypertension. The authors determined that the presence of mutant variants of two genes that encode mitochondrial proteins reduced the efficacy of the treatment, suggesting that clinical trial design could benefit from considering patients' genotypes. [CREDIT: E. MICHELAKIS/UNIVERSITY OF ALBERTA]