Editors' ChoiceImmunology

Nuclear jailbreak: DNA escapes and inflames

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Science Translational Medicine  18 Oct 2017:
Vol. 9, Issue 412, eaap8171
DOI: 10.1126/scitranslmed.aap8171

Abstract

Cytosolic DNA sensors detect fragmented or damaged DNA that escapes the nucleus during cellular senescence or cancer and induces inflammation.

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