Research ArticleInfluenza

A multimechanistic antibody targeting the receptor binding site potently cross-protects against influenza B viruses

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Science Translational Medicine  18 Oct 2017:
Vol. 9, Issue 412, eaam5752
DOI: 10.1126/scitranslmed.aam5752

An antibody to battle flu B

Although it circulates globally and is prevalent enough to warrant inclusion in the seasonal influenza vaccine, influenza B is far less well studied than its cousin, influenza A, and therapeutics are lacking. Shen et al. have now generated a potent antibody that inhibits diverse strains of influenza B virus. The antibody recognizes the receptor binding site in hemagglutinin, a region critical to viral entry, and was shown to be therapeutically effective in mice and ferrets. This antibody could be widely deployed to treat or prevent influenza B infection around the world.