18 October 2017
Vol 9, Issue 412

About The Cover

Cover image expansion

ONLINE COVER The Tell-Tale Tracks of a Carcinogen. The plant depicted here is part of the genus Aristolochia, which includes multiple species used in traditional herbal medicine. Aristolochic acids, which are compounds found in these plants, are known carcinogens that affect the urinary tract. In this issue, Ng et al. report that the damage induced by aristolochic acids goes well beyond the urinary system and the genetic signature of this carcinogen is frequently found in liver cancers, a much more common tumor type, despite a ban on the use of Aristolochia supplements in Taiwan and other countries. [CREDIT: FRANCISCO MANUEL BLANCO/WIKIMEDIA COMMONS]