Research ArticleCardiovascular Disease

High-density lipoprotein delivered after myocardial infarction increases cardiac glucose uptake and function in mice

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Science Translational Medicine  11 Oct 2017:
Vol. 9, Issue 411, eaam6084
DOI: 10.1126/scitranslmed.aam6084

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Lipoprotein lends a hand for heart attacks

Preventing myocyte damage after myocardial infarction could help stop the development of heart failure. Heywood et al. administered reconstituted high-density lipoprotein (rHDL) after inducing cardiac ischemia in mice and showed that treatment caused increased glucose uptake in myocytes, reduced infarct size, and improved ventricle function. rHDL was effective in prediabetic and healthy mice, suggesting that it may be a promising treatment for acute coronary syndrome.