Contents
11 October 2017
Vol 9, Issue 411
Vol 9, Issue 411
Research Articles
- Functional ultrasound imaging of brain activity in human newborns
Functional ultrasound imaging with high spatiotemporal resolution monitors brain function in babies.
- High-density lipoprotein delivered after myocardial infarction increases cardiac glucose uptake and function in mice
One dose of rHDL after myocardial ischemia increases both cardiac glucose uptake and heart function in healthy and insulin-resistant mice.
- Preclinical modeling highlights the therapeutic potential of hematopoietic stem cell gene editing for correction of SCID-X1
Preclinical studies establish the conditions for safe and effective correction of SCID-X1 by targeted gene editing of hematopoietic stem cells.
- An analysis of IL-36 signature genes and individuals with IL1RL2 knockout mutations validates IL-36 as a psoriasis therapeutic target
IL-36 receptor (IL-36R) blockade ameliorates psoriatic inflammation and should be well tolerated, because IL-36R knockout mutations are benign.
Editors' Choice
- Check twice, cut once—Improved CRISPR-Cas9 genome editing accuracy
Based on observations of the mechanism underlying target discrimination, researchers have developed highly accurate variants of CRISPR-Cas9.
- Less is more for anticancer therapy combinations
Withdrawal of MAPK inhibition sensitizes cancer cells to DNA repair–targeting drugs.
- Lurking culprits
IL-17–producing T cells persist in resolved psoriatic skin lesions.
- The science of love in ASD and ADHD
Genetic variations in the oxytocin receptor gene affect patients with ASD and ADHD differently.
About The Cover
ONLINE COVER A Peek into the Neonatal Brain. Using continuous ultrasound imaging combined with video-electroencephalographic recording, Demene et al. developed a portable noninvasive technology called fUSI that simultaneously monitors brain vascular changes and electric activity in neonates at the bedside. The cover shows an ultrasound coronal image of the brain vasculature in a newborn baby during active sleep. [CREDIT: DEMENE ET AL./SCIENCE TRANSLATIONAL MEDICINE]