Neutralizing human monoclonal antibodies prevent Zika virus infection in macaques

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Science Translational Medicine  04 Oct 2017:
Vol. 9, Issue 410, eaan8184
DOI: 10.1126/scitranslmed.aan8184

Antibodies provide promising Zika prophylaxis

The recent Zika virus epidemic and ensuing fetal consequences caught the world off guard. Scientists are now scrambling for information on Zika virus detection, treatment, and prevention. Passive immunity provided by monoclonal antibodies offers an attractive alternative to traditional vaccines, because it can be generated relatively quickly. Magnani et al. isolated and engineered three neutralizing antibodies from a Zika-infected patient. Administration of these antibodies completely protected nonhuman primates from becoming infected with Zika virus, suggesting that such a cocktail could be used to prevent Zika infections in people.

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