Engineering a highly elastic human protein–based sealant for surgical applications

Nasim Annabi; Yi-Nan Zhang; Alexander Assmann; Ehsan Shirzaei Sani; George Cheng; Antonio D. Lassaletta; Andrea Vegh; Bijan Dehghani; Guillermo U. Ruiz-Esparza; Xichi Wang; Sidhu Gangadharan; Anthony S. Weiss; Ali Khademhosseini

doi:10.1126/scitranslmed.aai7466

Research ArticleBIOMATERIALS

Engineering a highly elastic human protein–based sealant for surgical applications

View ORCID ProfileNasim Annabi¹,²,³,⁴,*,
Yi-Nan Zhang²,³,†,
Alexander Assmann²,³,⁴,⁵,
Ehsan Shirzaei Sani¹,
George Cheng⁶,
View ORCID ProfileAntonio D. Lassaletta⁶,
Andrea Vegh²,³,
Bijan Dehghani²,³,
Guillermo U. Ruiz-Esparza²,³,
View ORCID ProfileXichi Wang²,³,
View ORCID ProfileSidhu Gangadharan⁶,
View ORCID ProfileAnthony S. Weiss⁷,⁸,⁹ and
View ORCID ProfileAli Khademhosseini²,³,⁴,¹⁰,*

¹Department of Chemical Engineering, Northeastern University, Boston, MA 02115–5000, USA.
²Biomaterials Innovation Research Center, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02139, USA.
³Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
⁴Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02115, USA.
⁵Department of Cardiovascular Surgery and Research Group for Experimental Surgery, Heinrich Heine University, Medical Faculty, Duesseldorf 40225, Germany.
⁶Division of Thoracic Surgery and Interventional Pulmonology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA.
⁷School of Life and Environmental Sciences, University of Sydney, Sydney, New South Wales 2006, Australia.
⁸Charles Perkins Centre, University of Sydney, Sydney, New South Wales 2006, Australia.
⁹Bosch Institute, University of Sydney, Sydney, New South Wales 2006, Australia.
¹⁰Department of Physics, King Abdulaziz University, Jeddah 21569, Saudi Arabia.

↵*Corresponding author. Email: n.annabi{at}neu.edu (N.A.); alik{at}bwh.harvard.edu (A.K.)

↵† Present address: Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, ON M5S 3G9, Canada.

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Science Translational Medicine 04 Oct 2017:
Vol. 9, Issue 410, eaai7466
DOI: 10.1126/scitranslmed.aai7466

Nasim Annabi

1Department of Chemical Engineering, Northeastern University, Boston, MA 02115–5000, USA.

2Biomaterials Innovation Research Center, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02139, USA.

3Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

4Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02115, USA.

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ORCID record for Nasim Annabi
For correspondence: n.annabi@neu.edu alik@bwh.harvard.edu

Yi-Nan Zhang

2Biomaterials Innovation Research Center, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02139, USA.

3Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

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Alexander Assmann

2Biomaterials Innovation Research Center, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02139, USA.

3Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

4Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02115, USA.

5Department of Cardiovascular Surgery and Research Group for Experimental Surgery, Heinrich Heine University, Medical Faculty, Duesseldorf 40225, Germany.

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Ehsan Shirzaei Sani

1Department of Chemical Engineering, Northeastern University, Boston, MA 02115–5000, USA.

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George Cheng

6Division of Thoracic Surgery and Interventional Pulmonology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA.

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Antonio D. Lassaletta

6Division of Thoracic Surgery and Interventional Pulmonology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA.

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ORCID record for Antonio D. Lassaletta

Andrea Vegh

2Biomaterials Innovation Research Center, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02139, USA.

3Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

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Bijan Dehghani

2Biomaterials Innovation Research Center, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02139, USA.

3Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

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Guillermo U. Ruiz-Esparza

2Biomaterials Innovation Research Center, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02139, USA.

3Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

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Xichi Wang

2Biomaterials Innovation Research Center, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02139, USA.

3Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

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Sidhu Gangadharan

6Division of Thoracic Surgery and Interventional Pulmonology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA.

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Anthony S. Weiss

7School of Life and Environmental Sciences, University of Sydney, Sydney, New South Wales 2006, Australia.

8Charles Perkins Centre, University of Sydney, Sydney, New South Wales 2006, Australia.

9Bosch Institute, University of Sydney, Sydney, New South Wales 2006, Australia.

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Ali Khademhosseini

2Biomaterials Innovation Research Center, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02139, USA.

3Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

4Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02115, USA.

10Department of Physics, King Abdulaziz University, Jeddah 21569, Saudi Arabia.

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ORCID record for Ali Khademhosseini
For correspondence: n.annabi@neu.edu alik@bwh.harvard.edu

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A highly elastic and adhesive photocrosslinkable surgical sealant using a modified human protein controls liquid leakages without the need for suturing.

Engineering a highly elastic human protein–based sealant for surgical applications

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