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Research ArticleBIOMATERIALS
Engineering a highly elastic human protein–based sealant for surgical applications
- View ORCID ProfileNasim Annabi1,2,3,4,*,
- Yi-Nan Zhang2,3,†,
- Alexander Assmann2,3,4,5,
- Ehsan Shirzaei Sani1,
- George Cheng6,
- View ORCID ProfileAntonio D. Lassaletta6,
- Andrea Vegh2,3,
- Bijan Dehghani2,3,
- Guillermo U. Ruiz-Esparza2,3,
- View ORCID ProfileXichi Wang2,3,
- View ORCID ProfileSidhu Gangadharan6,
- View ORCID ProfileAnthony S. Weiss7,8,9 and
- View ORCID ProfileAli Khademhosseini2,3,4,10,*
- 1Department of Chemical Engineering, Northeastern University, Boston, MA 02115–5000, USA.
- 2Biomaterials Innovation Research Center, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02139, USA.
- 3Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
- 4Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02115, USA.
- 5Department of Cardiovascular Surgery and Research Group for Experimental Surgery, Heinrich Heine University, Medical Faculty, Duesseldorf 40225, Germany.
- 6Division of Thoracic Surgery and Interventional Pulmonology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA.
- 7School of Life and Environmental Sciences, University of Sydney, Sydney, New South Wales 2006, Australia.
- 8Charles Perkins Centre, University of Sydney, Sydney, New South Wales 2006, Australia.
- 9Bosch Institute, University of Sydney, Sydney, New South Wales 2006, Australia.
- 10Department of Physics, King Abdulaziz University, Jeddah 21569, Saudi Arabia.
- ↵*Corresponding author. Email: n.annabi{at}neu.edu (N.A.); alik{at}bwh.harvard.edu (A.K.)
↵† Present address: Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, ON M5S 3G9, Canada.
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Science Translational Medicine 04 Oct 2017:
Vol. 9, Issue 410, eaai7466
DOI: 10.1126/scitranslmed.aai7466
Vol. 9, Issue 410, eaai7466
DOI: 10.1126/scitranslmed.aai7466
Nasim Annabi
1Department of Chemical Engineering, Northeastern University, Boston, MA 02115–5000, USA.
2Biomaterials Innovation Research Center, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02139, USA.
3Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
4Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02115, USA.
Yi-Nan Zhang
2Biomaterials Innovation Research Center, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02139, USA.
3Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Alexander Assmann
2Biomaterials Innovation Research Center, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02139, USA.
3Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
4Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02115, USA.
5Department of Cardiovascular Surgery and Research Group for Experimental Surgery, Heinrich Heine University, Medical Faculty, Duesseldorf 40225, Germany.
Ehsan Shirzaei Sani
1Department of Chemical Engineering, Northeastern University, Boston, MA 02115–5000, USA.
George Cheng
6Division of Thoracic Surgery and Interventional Pulmonology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA.
Antonio D. Lassaletta
6Division of Thoracic Surgery and Interventional Pulmonology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA.
Andrea Vegh
2Biomaterials Innovation Research Center, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02139, USA.
3Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Bijan Dehghani
2Biomaterials Innovation Research Center, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02139, USA.
3Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Guillermo U. Ruiz-Esparza
2Biomaterials Innovation Research Center, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02139, USA.
3Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Xichi Wang
2Biomaterials Innovation Research Center, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02139, USA.
3Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Sidhu Gangadharan
6Division of Thoracic Surgery and Interventional Pulmonology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA.
Anthony S. Weiss
7School of Life and Environmental Sciences, University of Sydney, Sydney, New South Wales 2006, Australia.
8Charles Perkins Centre, University of Sydney, Sydney, New South Wales 2006, Australia.
9Bosch Institute, University of Sydney, Sydney, New South Wales 2006, Australia.
Ali Khademhosseini
2Biomaterials Innovation Research Center, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02139, USA.
3Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
4Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02115, USA.
10Department of Physics, King Abdulaziz University, Jeddah 21569, Saudi Arabia.
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