Research ArticleInfectious Disease

RNAi-based treatment of chronically infected patients and chimpanzees reveals that integrated hepatitis B virus DNA is a source of HBsAg

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Science Translational Medicine  27 Sep 2017:
Vol. 9, Issue 409, eaan0241
DOI: 10.1126/scitranslmed.aan0241

Article Information

vol. 9 no. 409

PubMed: 
Print ISSN: 
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History: 
  • Received for publication February 21, 2017
  • Accepted for publication August 4, 2017
  • .

Author Information

  1. Christine I. Wooddell1,*,,
  2. Man-Fung Yuen2,*,
  3. Henry Lik-Yuen Chan3,
  4. Robert G. Gish4,
  5. Stephen A. Locarnini5,6,
  6. Deborah Chavez7,
  7. Carlo Ferrari8,9,
  8. Bruce D. Given1,
  9. James Hamilton10,
  10. Steven B. Kanner1,
  11. Ching-Lung Lai2,
  12. Johnson Y. N. Lau11,
  13. Thomas Schluep10,
  14. Zhao Xu1,
  15. Robert E. Lanford7 and
  16. David L. Lewis1
  1. 1Arrowhead Pharmaceuticals, 502 South Rosa Road, Madison, WI 53719, USA.
  2. 2Department of Medicine, University of Hong Kong, Queen Mary Hospital, Hong Kong, China.
  3. 3Department of Medicine and Therapeutics and Institute of Digestive Disease, Chinese University of Hong Kong, Hong Kong, China.
  4. 4Liver Transplant Program, Stanford University Medical Center, San Diego, CA 92037, USA.
  5. 5Victorian Infectious Diseases Reference Laboratory, Melbourne, Victoria 3000, Australia.
  6. 6WHO Regional Reference Laboratory for Hepatitis B, Doherty Institute, Melbourne, Victoria, Australia.
  7. 7Southwest National Primate Research Center, Texas Biomedical Research Institute, San Antonio, TX 78227, USA.
  8. 8Unit of Infectious Diseases and Hepatology, University of Parma, Parma 43126, Italy.
  9. 9Azienda Ospedaliero-Universitaria of Parma, Parma 43126, Italy.
  10. 10Arrowhead Pharmaceuticals, 225 South Lake Avenue, Suite 1050, Pasadena, CA 91101, USA.
  11. 11Hong Kong Polytechnic University, Hong Kong, China.
  1. Corresponding author. Email: cwooddell{at}arrowheadpharma.com
    • * These authors contributed equally to this work.

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