27 September 2017
Vol 9, Issue 409

About The Cover

Cover image expansion

ONLINE COVER Aggravating Aggregates. Critically ill patients with gut ischemia can have unfortunate complications due to thrombosis in distant organs. The thrombotic response involves neutrophils, and in this issue Yuan et al. examined how this process unfolds and a potentially new way to interrupt it. They discovered that rolling neutrophils rip fragments from dying platelets, which instigates the formation of macroaggregates and vascular occlusion. Such macroaggregates do not respond to typical antiplatelet drugs and might need to be targeted in other ways. Shown here is a three-dimensional rendering of human neutrophils (red) bridging platelet remnants (green) to form aggregates. [CREDIT: YUAN ET AL./SCIENCE TRANSLATIONAL MEDICINE]