Contents
27 September 2017
Vol 9, Issue 409
Vol 9, Issue 409
Research Articles
- Neutrophil macroaggregates promote widespread pulmonary thrombosis after gut ischemia
Neutrophil macroaggregates induce a distinct arterial-venous thrombotic response in the lung after gut ischemia.
- RNAi-based treatment of chronically infected patients and chimpanzees reveals that integrated hepatitis B virus DNA is a source of HBsAg
The hepatitis B virus surface antigen, key to maintaining chronic infection, is expressed from viral DNA integrated into the host chromosome.
- Hyperpolarization-activated cyclic nucleotide–gated 2 (HCN2) ion channels drive pain in mouse models of diabetic neuropathy
Blocking HCN2 ion channel activity in peripheral nociceptive neurons alleviates the pain hypersensitivity associated with diabetic neuropathy.
- Rapid antigen tests for dengue virus serotypes and Zika virus in patient serum
A low-cost, equipment-free rapid antigen test distinguishes dengue virus serotypes and Zika virus in patient sera without detectable cross-reactivity.
- Human pluripotent stem cell–derived erythropoietin-producing cells ameliorate renal anemia in mice
iPSC-derived cells can secrete functional erythropoietin in a physiological manner and ameliorate renal anemia in a mouse model.
Editors' Choice
- A game of thrones and broken bones
Repair of cranial bone trauma with degradable magnesium implants could reduce complications and eliminate the need for implant removal.
- Genomics are CReePing up on inflammation in PTSD
Posttraumatic stress disorder is linked to increased blood and genetic and epigenetic markers of C-reactive protein.
- Foe becomes friend as Zika joins the fight against cancer
Zika virus preferentially targets cancer stem cells in glioblastoma, resulting in reduced tumor growth.
About The Cover
ONLINE COVER Aggravating Aggregates. Critically ill patients with gut ischemia can have unfortunate complications due to thrombosis in distant organs. The thrombotic response involves neutrophils, and in this issue Yuan et al. examined how this process unfolds and a potentially new way to interrupt it. They discovered that rolling neutrophils rip fragments from dying platelets, which instigates the formation of macroaggregates and vascular occlusion. Such macroaggregates do not respond to typical antiplatelet drugs and might need to be targeted in other ways. Shown here is a three-dimensional rendering of human neutrophils (red) bridging platelet remnants (green) to form aggregates. [CREDIT: YUAN ET AL./SCIENCE TRANSLATIONAL MEDICINE]
