Research ArticleCARDIAC IMAGING
Responsive monitoring of mitochondrial redox states in heart muscle predicts impending cardiac arrest
- Dorothy A. Perry1,2,*,
- Joshua W. Salvin1,2,*,
- Padraic Romfh3,
- Peili Chen3,
- Kalyani Krishnamurthy3,
- Lindsay M. Thomson1,
- Brian D. Polizzotti1,2,
- Francis X. McGowan4,5,
- Daryoosh Vakhshoori3,† and
- John N. Kheir1,2,†
- 1Department of Cardiology, Boston Children’s Hospital, Boston, MA 02115, USA.
- 2Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA.
- 3Pendar Technologies, Cambridge, MA 02138, USA.
- 4Department of Anesthesiology and Critical Care Medicine, Children’s Hospital of Philadelphia, PA 19104, USA.
- 5Department of Anesthesiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
- ↵†Corresponding author. Email: dvakhshoori{at}pendar.tech (D.V.); john.kheir{at}childrens.harvard.edu (J.N.K.)
↵* These authors contributed equally to this work.
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Science Translational Medicine 20 Sep 2017:
Vol. 9, Issue 408, eaan0117
DOI: 10.1126/scitranslmed.aan0117
Vol. 9, Issue 408, eaan0117
DOI: 10.1126/scitranslmed.aan0117
Dorothy A. Perry
Department of Cardiology, Boston Children’s Hospital, Boston, MA 02115, USA.Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA.
Joshua W. Salvin
Department of Cardiology, Boston Children’s Hospital, Boston, MA 02115, USA.Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA.
Padraic Romfh
Pendar Technologies, Cambridge, MA 02138, USA.
Peili Chen
Pendar Technologies, Cambridge, MA 02138, USA.
Kalyani Krishnamurthy
Pendar Technologies, Cambridge, MA 02138, USA.
Lindsay M. Thomson
Department of Cardiology, Boston Children’s Hospital, Boston, MA 02115, USA.
Brian D. Polizzotti
Department of Cardiology, Boston Children’s Hospital, Boston, MA 02115, USA.Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA.
Francis X. McGowan
Department of Anesthesiology and Critical Care Medicine, Children’s Hospital of Philadelphia, PA 19104, USA.Department of Anesthesiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Daryoosh Vakhshoori
Pendar Technologies, Cambridge, MA 02138, USA.
John N. Kheir
Department of Cardiology, Boston Children’s Hospital, Boston, MA 02115, USA.Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA.
