Targeted inhibition of Gq signaling induces airway relaxation in mouse models of asthma

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Science Translational Medicine  13 Sep 2017:
Vol. 9, Issue 407, eaag2288
DOI: 10.1126/scitranslmed.aag2288

Breathing freely

Obstructive lung diseases are common disorders characterized by airway narrowing. Because some patients do not respond well to current therapies or suffer from side effects, new drugs are needed. Matthey et al. now report that the selective Gq inhibitor FR900359 reduces airway tone in mouse, pig, and human airways ex vivo and decreases airway resistance in mouse models of asthma in vivo. The compound has the advantage that it can be locally applied to the lung via inhalation and shows promising properties that may prove useful for treating obstructive airway disease.

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