Research ArticleHIV
Broadly neutralizing antibodies targeting the HIV-1 envelope V2 apex confer protection against a clade C SHIV challenge
- View ORCID ProfileBoris Julg1,2,*,
- View ORCID ProfileLawrence J. Tartaglia2,*,
- View ORCID ProfileBrandon F. Keele3,
- Kshitij Wagh4,
- View ORCID ProfileAmarendra Pegu5,
- View ORCID ProfileDevin Sok6,
- View ORCID ProfilePeter Abbink2,
- View ORCID ProfileStephen D. Schmidt5,
- Keyun Wang5,
- View ORCID ProfileXuejun Chen5,
- View ORCID ProfileM. Gordon Joyce5,
- Ivelin S. Georgiev5,
- View ORCID ProfileMisook Choe5,
- View ORCID ProfilePeter D. Kwong5,
- View ORCID ProfileNicole A. Doria-Rose5,
- View ORCID ProfileKhoa Le6,
- View ORCID ProfileMark K. Louder5,
- Robert T. Bailer5,
- View ORCID ProfilePenny L. Moore7,8,
- View ORCID ProfileBette Korber4,
- View ORCID ProfileMichael S. Seaman2,
- View ORCID ProfileSalim S. Abdool Karim8,9,
- View ORCID ProfileLynn Morris7,8,
- Richard A. Koup5,
- View ORCID ProfileJohn R. Mascola5,
- View ORCID ProfileDennis R. Burton1,6 and
- View ORCID ProfileDan H. Barouch1,2,†
- 1Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Harvard University, Cambridge, MA 02139, USA.
- 2Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA 02115, USA.
- 3AIDS and Cancer Virus Program, Leidos Biomedical Research Inc., Frederick National Laboratory for Cancer Research, Frederick, MD 21702, USA.
- 4Los Alamos National Laboratory, Los Alamos, NM 87545, USA.
- 5Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20814, USA.
- 6The Scripps Research Institute, La Jolla, CA 92037, USA.
- 7National Institute for Communicable Diseases of the National Health Laboratory Service and the University of the Witwatersrand, 2131 Johannesburg, South Africa.
- 8Centre for the AIDS Programme of Research in South Africa, 4013 Durban, South Africa.
- 9Columbia University, New York, NY 10032, USA.
- ↵†Corresponding author. Email: dbarouch{at}bidmc.harvard.edu
↵* These authors contributed equally to this work.
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Science Translational Medicine 06 Sep 2017:
Vol. 9, Issue 406, eaal1321
DOI: 10.1126/scitranslmed.aal1321
Vol. 9, Issue 406, eaal1321
DOI: 10.1126/scitranslmed.aal1321
Boris Julg
1Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Harvard University, Cambridge, MA 02139, USA.
2Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA 02115, USA.
Lawrence J. Tartaglia
2Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA 02115, USA.
Brandon F. Keele
3AIDS and Cancer Virus Program, Leidos Biomedical Research Inc., Frederick National Laboratory for Cancer Research, Frederick, MD 21702, USA.
Kshitij Wagh
4Los Alamos National Laboratory, Los Alamos, NM 87545, USA.
Amarendra Pegu
5Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20814, USA.
Devin Sok
6The Scripps Research Institute, La Jolla, CA 92037, USA.
Peter Abbink
2Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA 02115, USA.
Stephen D. Schmidt
5Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20814, USA.
Keyun Wang
5Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20814, USA.
Xuejun Chen
5Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20814, USA.
M. Gordon Joyce
5Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20814, USA.
Ivelin S. Georgiev
5Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20814, USA.
Misook Choe
5Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20814, USA.
Peter D. Kwong
5Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20814, USA.
Nicole A. Doria-Rose
5Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20814, USA.
Khoa Le
6The Scripps Research Institute, La Jolla, CA 92037, USA.
Mark K. Louder
5Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20814, USA.
Robert T. Bailer
5Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20814, USA.
Penny L. Moore
7National Institute for Communicable Diseases of the National Health Laboratory Service and the University of the Witwatersrand, 2131 Johannesburg, South Africa.
8Centre for the AIDS Programme of Research in South Africa, 4013 Durban, South Africa.
Bette Korber
4Los Alamos National Laboratory, Los Alamos, NM 87545, USA.
Michael S. Seaman
2Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA 02115, USA.
Salim S. Abdool Karim
8Centre for the AIDS Programme of Research in South Africa, 4013 Durban, South Africa.
9Columbia University, New York, NY 10032, USA.
Lynn Morris
7National Institute for Communicable Diseases of the National Health Laboratory Service and the University of the Witwatersrand, 2131 Johannesburg, South Africa.
8Centre for the AIDS Programme of Research in South Africa, 4013 Durban, South Africa.
Richard A. Koup
5Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20814, USA.
John R. Mascola
5Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20814, USA.
Dennis R. Burton
1Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Harvard University, Cambridge, MA 02139, USA.
6The Scripps Research Institute, La Jolla, CA 92037, USA.
Dan H. Barouch
1Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Harvard University, Cambridge, MA 02139, USA.
2Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA 02115, USA.
