Contents
06 September 2017
Vol 9, Issue 406
Vol 9, Issue 406
Research Articles
- Nondestructive tissue analysis for ex vivo and in vivo cancer diagnosis using a handheld mass spectrometry system
A handheld and biocompatible mass spectrometry system provides nondestructive molecular diagnosis of cancer tissue samples.
- Broadly neutralizing antibodies targeting the HIV-1 envelope V2 apex confer protection against a clade C SHIV challenge
Neutralizing antibodies to the HIV-1 envelope V2 apex protect macaques against SHIV challenge at very low serum concentrations.
- New class of precision antimicrobials redefines role of Clostridium difficile S-layer in virulence and viability
Rare Clostridium difficile mutants lacking surface-layer protein A escape killing by Avidocin-CDs and display severe phenotypic defects that compromise virulence in animals.
- Synthetic oligosaccharides can replace animal-sourced low–molecular weight heparins
A synthetic homogeneous low–molecular weight heparin provides a safe and effective therapeutic alternative.
Editors' Choice
- Queuing up for resistance testing
Antibiotic resistance in Escherichia coli can be assessed by real-time imaging of bacterial replication in a microfluidics system.
- A tale of two amyloids
Plasma β-amyloid drives peripheral insulin resistance, which precedes an increase in cerebral neuropathology in a novel mouse model that combines Alzheimer’s and diabetes pathologies.
- Single-cell nuclei rise from the dead
High throughput, single-cell transcriptomic profiling can rapidly profile frozen mouse and human tissues.
- ILCregs: The new kid in class
ILCregs are a population of innate lymphoid cells that control innate intestinal inflammation through IL-10.
About The Cover
ONLINE COVER The Write Tool for the Job. To rapidly identify cancerous tissue in situ, Zhang et al. developed the MasSpec Pen, shown here in simulation. The handheld device uses a small volume water droplet to pick up molecules from the tissue surface (see inset) and transports the droplet to an attached mass spectrometer, where the molecules are analyzed. The device distinguished healthy human tissues from cancerous specimens, and identified tumors in mice when used intraoperatively. This mighty pen offers surgeons a nondestructive tool to add to their arsenal to distinguish healthy from tumor tissue. [CREDIT: LIVIA S. EBERLIN, JIALING ZHANG, NOAH GIESE/THE UNIVERSITY OF TEXAS AT AUSTIN]