Research ArticleHIV

Inflammatory monocytes expressing tissue factor drive SIV and HIV coagulopathy

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Science Translational Medicine  30 Aug 2017:
Vol. 9, Issue 405, eaam5441
DOI: 10.1126/scitranslmed.aam5441

Article Information

vol. 9 no. 405

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History: 
  • Received for publication December 6, 2016
  • Accepted for publication July 11, 2017
  • .

Author Information

  1. Melissa E. Schechter1,*,
  2. Bruno B. Andrade2,3,4,5,6,*,,
  3. Tianyu He7,8,*,
  4. George Haret Richter7,
  5. Kevin W. Tosh2,
  6. Benjamin B. Policicchio7,9,
  7. Amrit Singh10,
  8. Kevin D. Raehtz7,11,
  9. Virginia Sheikh10,
  10. Dongying Ma12,
  11. Egidio Brocca-Cofano7,8,
  12. Cristian Apetrei7,11,
  13. Russel Tracy13,
  14. Ruy M. Ribeiro14,15,
  15. Alan Sher2,
  16. Ivo M. B. Francischetti12,
  17. Ivona Pandrea7,8,, and
  18. Irini Sereti10,,
  1. 1Clinical Research Directorate/Clinical Monitoring Research Program, Leidos Biomedical Research Inc., Frederick National Laboratory for Cancer Research, Frederick, MD 21701, USA.
  2. 2Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
  3. 3Instituto Gonçalo Moniz, Fundação Oswaldo Cruz, Salvador 40296-710, Brazil.
  4. 4Multinational Organization Network Sponsoring Translational and Epidemiological Research (MONSTER) Initiative, Instituto Brasileiro para a Investigação da Tuberculose, Fundação José Silveira, Salvador 40210-320, Brazil.
  5. 5Wellcome Centre for Infectious Disease Research in Africa, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town 7925, South Africa.
  6. 6Division of Infectious Diseases, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.
  7. 7Center for Vaccine Research, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA.
  8. 8Department of Pathology, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA.
  9. 9Department of Infectious Diseases and Microbiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA.
  10. 10HIV Pathogenesis Section, Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
  11. 11Department of Microbiology and Molecular Genetics, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA.
  12. 12Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
  13. 13Department of Pathology and Laboratory Medicine, The Robert Larner, M.D. College of Medicine University of Vermont, Burlington, VT 05405, USA.
  14. 14Theoretical Biology and Biophysics, Los Alamos National Laboratory, Los Alamos, NM 87544, USA.
  15. 15Laboratório de Biomatemática, Faculdade de Medicina, Universidade de Lisboa, Lisboa 1649-028, Portugal.
  1. Corresponding author. Email: bruno.andrade{at}bahia.fiocruz.br (B.B.A.); isereti{at}niaid.nih.gov (I.S.); pandrea{at}pitt.edu (I.P.)
    • * These authors contributed equally to this work.

    • These authors contributed equally to this work.

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